Tyrphostin 51

CAS 126433-07-6C13H8N4O3Biochemicals & Reagents

Tyrphostin 51 (CAS: 126433-07-6), with the molecular formula C13H8N4O3 and a molecular weight of 268.23 g/mol, is a potent inhibitor of various tyrosine kinases, notably EGFR. It is commonly employed in biochemical research to investigate cellular signalling pathways. This compound has been utilized in studies concerning the inhibition of rat hepatic leptin and serves as a valuable tool for understanding kinase biology and developing targeted therapies.

IUPAC: 2-Amino-1,1,3-tricyano-4-(3′,4′,5′-trihydroxyphenyl)butadiene

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Tyrphostin 51 (C13H8N4O3) — chemical structure, CAS 126433-07-6; Life Science, fine chemical supplied by Tech Serve Solutions

Bioactive Small MoleculesBiochemicals and ReagentsCell BiologyEnzyme InhibitorsEnzyme Inhibitors by EnzymeEnzymesInhibitorsand SubstratesKinase/Phosphatase BiologyP to Q

01 /Applications

EGFR Kinase Inhibition Studies

Tyrphostin 51 is a well-characterised inhibitor of Epidermal Growth Factor Receptor (EGFR) tyrosine kinase. It is frequently used in research to explore the role of EGFR signalling in cellular proliferation and differentiation.

Leptin Signalling Research

This compound has been applied in research to investigate the inhibition of rat hepatic leptin, contributing to a deeper understanding of leptin's role in metabolic regulation and related pathways.

Cellular Signalling Pathway Analysis

As a bioactive small molecule, Tyrphostin 51 is instrumental in dissecting complex cellular signalling cascades, particularly those involving tyrosine phosphorylation events in neuroscience and cell biology.

02 /Properties

Molecular weight	268.23
Empirical formula	C13H8N4O3
Assay	≥98%
Solubility	DMSO: soluble5 mg of Tyrphostin 51 in 0.1 ml of solvent, clear, orange to red
Storage temperature	2-8°C
Application	Tyrphostin 51 has been used to study the inhibition of rat hepatic leptin 11.

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

126433-07-6

MDL number

MFCD00133903

PubChem substance

24278756

05 /Additional specifications

Gene Information	human ... CDK2(1017), EGFR(1956)
Potency	0.8 μM IC50

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is Tyrphostin 51 primarily used for?

Tyrphostin 51 is primarily used in research as an inhibitor of Epidermal Growth Factor Receptor (EGFR) tyrosine kinase and in studies investigating the inhibition of rat hepatic leptin.

What is the CAS number and formula for Tyrphostin 51?

The CAS number for Tyrphostin 51 is 126433-07-6, and its molecular formula is C13H8N4O3.

What grade and purity does Tech Serve Solutions supply for Tyrphostin 51?

Tech Serve Solutions supplies Tyrphostin 51 with a purity of ≥98% (Assay). This product is intended for research and laboratory use only and is not supplied as USP, BP, EP, or pharmaceutical grade.

What are the safety precautions for handling Tyrphostin 51?

When handling Tyrphostin 51, it is essential to use personal protective equipment including eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter. The product carries a WGK Germany rating of 3, indicating a significant hazard to water.

How is Tyrphostin 51 stored and shipped?

Tyrphostin 51 should be stored at 2-8°C. Tech Serve Solutions is a specialist global supplier and exporter, ensuring proper packaging and handling for international shipments.

How can I request a sample or quote for Tyrphostin 51?

To request a sample or quote for Tyrphostin 51, please contact our sales team through the website or by phone. Provide the product name and CAS number for prompt service.