Fmoc-Phe(3-CN)-OH
Fmoc-Phe(3-CN)-OH (CAS 205526-36-9) is a protected unnatural amino acid derivative with the formula C25H20N2O4 and a molecular weight of 412.44 g/mol. This compound is primarily utilised in chemical synthesis and peptide chemistry. Its structure incorporates a cyano group on the phenylalanine ring, offering unique modification possibilities for peptide sequences in research and development.
- IUPAC
- Fmoc-3-cyano-L-phenylalanine
- Synonyms
- Fmoc-3-cyano-L-phenylalanine
Peptide Synthesis
Fmoc-Phe(3-CN)-OH serves as a building block in solid-phase peptide synthesis (SPPS) and solution-phase peptide synthesis. It allows for the incorporation of a non-canonical amino acid with a cyano-substituted phenyl ring into peptide chains.
Chemical Synthesis
This compound is employed as an intermediate in the synthesis of complex organic molecules. The cyano group provides a reactive handle for further chemical modifications and derivatisation.
Chemical Biology Research
Researchers use Fmoc-Phe(3-CN)-OH to introduce structural diversity into peptides, enabling the study of structure-activity relationships and the development of novel biomolecules with altered properties.
| Molecular weight | 412.44 |
|---|---|
| Empirical formula | C25H20N2O4 |
| Assay | ≥97.0% (HPLC) |
| Storage temperature | 2-8°C |
| Impurities tested | ~15% 2-propanol |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-Phe(3-CN)-OH used for?
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Fmoc-Phe(3-CN)-OH is used in chemical synthesis, peptide chemistry, and chemical biology research as a protected unnatural amino acid building block for introducing cyano-substituted phenylalanine into peptide sequences or other complex organic molecules.
What is the CAS number and formula for Fmoc-Phe(3-CN)-OH?
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The CAS number for Fmoc-Phe(3-CN)-OH is 205526-36-9, and its empirical formula is C25H20N2O4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-Phe(3-CN)-OH with an assay of ≥97.0% (HPLC). TSS does not represent this product as USP, BP, EP, or pharmacopoeia grade.
How should Fmoc-Phe(3-CN)-OH be handled safely?
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Handle Fmoc-Phe(3-CN)-OH with appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Note that it has a WGK Germany rating of 3, indicating a high hazard.
How is Fmoc-Phe(3-CN)-OH shipped and exported?
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Fmoc-Phe(3-CN)-OH is typically stored at 2-8°C. Tech Serve Solutions specialises in the global supply and export of fine chemicals, pharmaceutical intermediates, and laboratory reagents.
How can I request a sample or quote for Fmoc-Phe(3-CN)-OH?
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Please contact Tech Serve Solutions directly through our website or sales channels to request a sample or a quotation for Fmoc-Phe(3-CN)-OH.
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