Fmoc-Phe(3,4-F2)-OH

CAS 198560-43-94-F2)-OHChemical Synthesis

Fmoc-Phe(3,4-F2)-OH (CAS 198560-43-9) is a fluorinated unnatural amino acid derivative with the molecular formula C24H19F2NO4. This compound is primarily utilised in chemical synthesis and peptide chemistry. Its difluorinated phenylalanine structure makes it valuable for introducing specific structural and electronic properties into peptides, potentially influencing their conformation, stability, and biological activity in research settings.

IUPAC: Fmoc-3,4-difluoro-L-phenylalanine
Synonyms: Fmoc-3,4-difluoro-L-phenylalanine98% Fmoc-Phe(3,4-F2)-OHN-(9-Fluorenylmethoxycarbonyloxy)-3,4-difluoro-L-phenylalanine

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Fmoc-Phe(3,4-F2)-OH (4-F2)-OH) — chemical structure, CAS 198560-43-9; Chemistry, fine chemical supplied by Tech Serve Solutions

Chemical BiologyChemical SynthesisPeptide ChemistryPhenylalanine Derivatives

01 /Applications

Peptide Synthesis

Fmoc-Phe(3,4-F2)-OH is employed as a building block in solid-phase peptide synthesis (SPPS) and solution-phase synthesis. It allows for the incorporation of a difluorinated phenylalanine residue, useful for modifying peptide properties such as receptor binding or metabolic stability.

Chemical Biology Research

This compound serves as a tool in chemical biology for creating modified peptides or proteins. The fluorine atoms can act as probes for NMR studies or subtly alter the electronic properties of the amino acid side chain, influencing molecular interactions.

Drug Discovery

As an unnatural amino acid derivative, Fmoc-Phe(3,4-F2)-OH can be incorporated into peptidomimetics or peptide-based drug candidates. Fluorination can enhance metabolic stability and lipophilicity, which are desirable characteristics in drug development.

Materials Science

Fluorinated amino acids can be used to synthesise novel peptides or polymers with specific material properties. The presence of fluorine can impact surface characteristics, self-assembly behaviour, and interactions with other materials.

02 /Properties

Molecular weight	423.41
Empirical formula	C24H19F2NO4
Assay	≥98.0% (HPLC)
Storage temperature	2-8°C

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

198560-43-9

MDL number

MFCD00672550

Beilstein registry

8947230

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Fmoc-Phe(3,4-F2)-OH used for?

Fmoc-Phe(3,4-F2)-OH is used in chemical synthesis, peptide chemistry, and chemical biology research as a building block for creating modified peptides and peptidomimetics. It is particularly useful for introducing a difluorinated phenylalanine residue.

What are the CAS number and formula for Fmoc-Phe(3,4-F2)-OH?

The CAS number for Fmoc-Phe(3,4-F2)-OH is 198560-43-9, and its empirical formula is C24H19F2NO4.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Fmoc-Phe(3,4-F2)-OH with an assay of ≥98.0% (HPLC). This is a research-grade chemical and is not supplied as USP, BP, EP, or pharmacopoeia grade.

What are the safety considerations for handling Fmoc-Phe(3,4-F2)-OH?

Handle Fmoc-Phe(3,4-F2)-OH with appropriate personal protective equipment, including eyeshields and gloves. Use a respirator with a type N95 (US) or P1 (EN143) filter if dust or aerosols are generated. The compound has a WGK Germany rating of 3, indicating a high hazard level.

How is Fmoc-Phe(3,4-F2)-OH stored and shipped?

Fmoc-Phe(3,4-F2)-OH should be stored at 2-8°C. TSS exports chemicals globally, adhering to all necessary shipping regulations for chemical compounds.

How can I request a sample or quote for Fmoc-Phe(3,4-F2)-OH?

To request a sample or a quote for Fmoc-Phe(3,4-F2)-OH, please contact the Tech Serve Solutions sales team through our website or by phone, providing your specific requirements.