Fmoc-Phe(3,4-Cl2)-OH
Fmoc-Phe(3,4-Cl2)-OH (CAS 177966-59-5) is a protected unnatural amino acid derivative with the molecular formula C24H19Cl2NO4 and a molecular weight of 456.32. It features a 3,4-dichlorinated phenylalanine residue protected by the Fmoc group, making it valuable in peptide synthesis. This compound is primarily utilised in chemical biology and advanced chemical synthesis for constructing complex peptide chains with specific structural modifications.
- IUPAC
- Fmoc-3,4-dichloro-L-phenylalanine
- Synonyms
- Fmoc-3,4-dichloro-L-phenylalanine
Peptide Synthesis
Fmoc-Phe(3,4-Cl2)-OH is a crucial building block in solid-phase peptide synthesis (SPPS). Its incorporation allows for the introduction of a dichlorinated phenylalanine residue, enabling the study of structure-activity relationships and the development of novel peptide-based therapeutics.
Chemical Biology Research
This unnatural amino acid derivative is employed in chemical biology to create peptides with altered properties. The chlorine substituents can influence peptide conformation, stability, and interactions, facilitating research into biological mechanisms and drug discovery.
Advanced Chemical Synthesis
Beyond peptide applications, Fmoc-Phe(3,4-Cl2)-OH serves as a versatile intermediate in complex organic synthesis. Its protected amino and carboxyl groups offer selective reactivity for constructing intricate molecular architectures.
| Molecular weight | 456.32 |
|---|---|
| Empirical formula | C24H19Cl2NO4 |
| Assay | ≥96.0% (HPLC) |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-Phe(3,4-Cl2)-OH used for?
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Fmoc-Phe(3,4-Cl2)-OH is primarily used as a building block in peptide synthesis, chemical biology research, and advanced chemical synthesis to introduce a 3,4-dichlorinated phenylalanine residue into peptide chains or other complex molecules.
What are the CAS number and formula for Fmoc-Phe(3,4-Cl2)-OH?
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The CAS number for Fmoc-Phe(3,4-Cl2)-OH is 177966-59-5, and its empirical formula (Hill notation) is C24H19Cl2NO4.
What grade and purity does Tech Serve Solutions supply for Fmoc-Phe(3,4-Cl2)-OH?
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Tech Serve Solutions supplies Fmoc-Phe(3,4-Cl2)-OH with a purity of ≥96.0% as determined by HPLC. This is a technical/research grade material, and TSS does not represent it as USP, BP, EP, or pharmacopoeia grade.
How should Fmoc-Phe(3,4-Cl2)-OH be handled and stored?
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Handle Fmoc-Phe(3,4-Cl2)-OH with appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or P1 (EN143) respirator filter is recommended. Store the chemical at 2-8°C.
Is Fmoc-Phe(3,4-Cl2)-OH a hazardous substance?
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Yes, Fmoc-Phe(3,4-Cl2)-OH is classified with a WGK (German water hazard class) of 3, indicating it is hazardous. Always consult the safety data sheet for detailed hazard information and handling procedures.
How is Fmoc-Phe(3,4-Cl2)-OH shipped?
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Tech Serve Solutions, as a global supplier and exporter, ships chemicals like Fmoc-Phe(3,4-Cl2)-OH in compliance with all relevant international shipping regulations. Storage during transit often follows recommended temperature guidelines where applicable.
How can I request a sample or quote for Fmoc-Phe(3,4-Cl2)-OH?
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To request a sample or obtain a quote for Fmoc-Phe(3,4-Cl2)-OH, please contact our sales department through the TSS website or direct inquiry channels.
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