Fmoc-Phe(2-Cl)-OH
Fmoc-Phe(2-Cl)-OH (CAS: 198560-41-7) is a protected unnatural amino acid derivative, specifically 2-chloro-L-phenylalanine. With a molecular weight of 421.87 g/mol and empirical formula C24H20ClNO4, it is a valuable building block in peptide synthesis. Its unique structure allows for the incorporation of modified phenylalanine residues into peptides, enabling the study of structure-activity relationships and the development of novel peptide-based therapeutics.
- IUPAC
- Fmoc-2-chloro-L-phenylalanine
Peptide Synthesis
Fmoc-Phe(2-Cl)-OH serves as a crucial reagent in solid-phase and solution-phase peptide synthesis. It allows for the site-specific incorporation of a chlorinated phenylalanine residue into peptide chains, facilitating the creation of modified peptides for research.
Chemical Biology Research
This unnatural amino acid derivative is employed in chemical biology to explore the impact of halogenation on peptide structure, stability, and biological activity. It can be used to probe protein-ligand interactions or develop peptide probes.
Drug Discovery and Development
The incorporation of Fmoc-Phe(2-Cl)-OH into peptide sequences can lead to analogues with altered pharmacological properties, such as increased metabolic stability or modified receptor binding affinity, aiding in the discovery of new drug candidates.
Organic Synthesis
As a functionalised phenylalanine derivative, it can be utilized in broader organic synthesis pathways where a protected, chlorinated aromatic amino acid moiety is required for constructing complex molecules.
| Molecular weight | 421.87 |
|---|---|
| Empirical formula | C24H20ClNO4 |
| Assay | ≥98.0% (HPLC) |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-Phe(2-Cl)-OH used for?
+
Fmoc-Phe(2-Cl)-OH is primarily used as a building block in peptide synthesis to incorporate unnatural, chlorinated phenylalanine residues. It is also valuable in chemical biology and drug discovery for creating modified peptides with altered properties for research purposes.
What are the CAS number and molecular formula for Fmoc-Phe(2-Cl)-OH?
+
The CAS number for Fmoc-Phe(2-Cl)-OH is 198560-41-7, and its empirical formula is C24H20ClNO4.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies Fmoc-Phe(2-Cl)-OH with an assay of ≥98.0% determined by HPLC. This product is intended for research and development purposes and is not represented as USP, BP, EP, or pharmaceutical grade.
How should Fmoc-Phe(2-Cl)-OH be handled and stored?
+
Handle Fmoc-Phe(2-Cl)-OH with appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Store the product at 2-8°C to maintain its stability and quality.
Does Tech Serve Solutions export Fmoc-Phe(2-Cl)-OH?
+
Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including Fmoc-Phe(2-Cl)-OH, and can fulfil export orders worldwide.
How can I request a quote or sample for Fmoc-Phe(2-Cl)-OH?
+
To request a quote or sample for Fmoc-Phe(2-Cl)-OH, please contact our sales team through the TSS website or by calling our dedicated customer service line.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis