Fmoc-Phe(2-CF3)-OH
Fmoc-Phe(2-CF3)-OH (CAS: 352523-16-1), with the molecular formula C25H20F3NO4 and a molecular weight of 455.43, is a specialized unnatural amino acid derivative. This trifluoromethyl-substituted phenylalanine analogue is primarily utilised in advanced chemical synthesis and peptide chemistry. Its unique structure makes it valuable for introducing specific conformational constraints or modified electronic properties into peptides, particularly in the field of chemical biology research.
- IUPAC
- Fmoc-2-(trifluoromethyl)-L-phenylalanine
Peptide Synthesis
Fmoc-Phe(2-CF3)-OH serves as a building block in solid-phase peptide synthesis (SPPS), allowing for the incorporation of unnatural amino acids. This enables the creation of peptides with enhanced stability, altered binding affinities, or novel biological activities.
Chemical Biology
This compound is employed in chemical biology to construct peptides and peptidomimetics with tailored properties. The trifluoromethyl group can influence hydrophobicity, metabolic stability, and molecular interactions, aiding in the study of biological systems.
Drug Discovery
As an unnatural amino acid derivative, Fmoc-Phe(2-CF3)-OH can be integrated into potential drug candidates to improve pharmacokinetic profiles or target specific biological pathways. Its unique structure offers a tool for medicinal chemists.
Material Science
Research involving the incorporation of fluorinated amino acids into peptide-based materials may utilise compounds like Fmoc-Phe(2-CF3)-OH to impart specific surface properties or self-assembly characteristics.
| Molecular weight | 455.43 |
|---|---|
| Empirical formula | C25H20F3NO4 |
| Assay | ≥98.0% (HPLC) |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-Phe(2-CF3)-OH used for?
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Fmoc-Phe(2-CF3)-OH is primarily used in peptide synthesis and chemical biology for creating peptides with modified properties, such as enhanced stability or altered binding affinities, due to its unnatural trifluoromethyl-substituted phenylalanine structure.
What are the CAS number and formula for Fmoc-Phe(2-CF3)-OH?
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The CAS number for Fmoc-Phe(2-CF3)-OH is 352523-16-1, and its molecular formula is C25H20F3NO4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-Phe(2-CF3)-OH with an assay of ≥98.0% (HPLC). We do not represent this product as USP, BP, EP, or pharmacopoeia grade.
How should Fmoc-Phe(2-CF3)-OH be handled and stored?
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Handle Fmoc-Phe(2-CF3)-OH with appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Store the product at 2-8°C.
Is Fmoc-Phe(2-CF3)-OH a controlled substance?
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Based on the provided data, there is no indication that Fmoc-Phe(2-CF3)-OH is a controlled substance.
How is Fmoc-Phe(2-CF3)-OH packed, shipped, and exported?
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Tech Serve Solutions exports a wide range of fine chemicals globally, adhering to all necessary shipping regulations for chemical products. Specific packaging details are available upon request.
How can I request a sample or quote for Fmoc-Phe(2-CF3)-OH?
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To request a sample or a quotation for Fmoc-Phe(2-CF3)-OH, please contact our sales department through the website or by calling our office.
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