Fmoc-Phe(3,5-F2)-OH

CAS 205526-24-55-F2)-OHChemical Synthesis

Fmoc-Phe(3,5-F2)-OH (CAS: 205526-24-5) is a synthetic, unnatural amino acid derivative featuring a difluorinated phenylalanine moiety protected with the Fmoc group. With a molecular weight of 423.41 g/mol and an empirical formula of C24H19F2NO4, this compound is primarily utilised in chemical synthesis, particularly within peptide chemistry and chemical biology research for the incorporation of modified amino acids into peptide chains.

IUPAC: Fmoc-3,5-difluoro-L-phenylalanine
Synonyms: Fmoc-3,5-difluoro-L-phenylalanineN-"((9H-fluoren-9-ylmethoxy)carbonyl)-3,5-difluorophenylalanine

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Fmoc-Phe(3,5-F2)-OH (5-F2)-OH) — chemical structure, CAS 205526-24-5; Chemistry, fine chemical supplied by Tech Serve Solutions

Chemical BiologyChemical SynthesisPeptide ChemistryPhenylalanine Derivatives

01 /Applications

Peptide Synthesis

Fmoc-Phe(3,5-F2)-OH serves as a specialised building block in solid-phase peptide synthesis (SPPS) and solution-phase methods. Its difluorinated structure allows for the introduction of unique properties into peptides, such as enhanced metabolic stability or altered binding characteristics.

Chemical Biology Research

This unnatural amino acid derivative is employed in chemical biology to create peptides with modified structures for investigating biological processes. The fluorine atoms can serve as useful probes for spectroscopic studies or influence the conformation and activity of the resulting biomolecules.

Medicinal Chemistry

In medicinal chemistry, Fmoc-Phe(3,5-F2)-OH can be incorporated into potential drug candidates to fine-tune pharmacokinetic properties like absorption, distribution, metabolism, and excretion (ADME). The difluoro substitution can impact lipophilicity and metabolic resistance.

Custom Synthesis

Researchers and developers may utilise this compound as a starting material or intermediate in custom synthesis projects requiring specialised phenylalanine analogues for novel compound development.

02 /Properties

Molecular weight	423.41
Empirical formula	C24H19F2NO4
Assay	≥98.0% (HPLC)

03 /Safety & handling

Hazard statements

H413May cause long-lasting harmful effects to aquatic life

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

205526-24-5

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Fmoc-Phe(3,5-F2)-OH used for?

Fmoc-Phe(3,5-F2)-OH is primarily used as a building block in chemical synthesis, particularly for creating modified peptides in peptide chemistry and for research applications in chemical biology and medicinal chemistry.

What is the CAS number and formula for Fmoc-Phe(3,5-F2)-OH?

The CAS number for Fmoc-Phe(3,5-F2)-OH is 205526-24-5, and its empirical formula is C24H19F2NO4.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Fmoc-Phe(3,5-F2)-OH with a purity of ≥98.0% (HPLC). This product is intended for research and laboratory use; TSS does not represent it as USP, BP, EP, or any other pharmacopoeia grade.

What are the safety and handling considerations for Fmoc-Phe(3,5-F2)-OH?

Fmoc-Phe(3,5-F2)-OH carries the hazard statement H413 (May cause long lasting harmful effects to aquatic life). It is recommended to use safety equipment including eyeshields and gloves, and a type N95 (US) or type P1 (EN143) respirator filter. Refer to the Safety Data Sheet (SDS) for comprehensive handling information.

Can Tech Serve Solutions export Fmoc-Phe(3,5-F2)-OH globally?

Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including Fmoc-Phe(3,5-F2)-OH. We handle all necessary export documentation and logistics.

How can I request a sample or a quote for Fmoc-Phe(3,5-F2)-OH?

To request a sample or a quote for Fmoc-Phe(3,5-F2)-OH, please contact our sales team through the website or by direct enquiry, providing your contact details and desired quantity.