Fmoc-Phe(3-CF3)-OH
Fmoc-Phe(3-CF3)-OH (CAS: 205526-27-8), with the molecular formula C25H20F3NO4 and a molecular weight of 455.43, is a specialised unnatural amino acid derivative. Utilised within peptide chemistry and chemical synthesis, this fluorinated phenylalanine analogue is integral to the development of novel peptides and complex organic molecules. Its unique trifluoromethyl substitution offers distinct properties for biochemical research and drug discovery.
- IUPAC
- Fmoc-3-(trifluoromethyl)-L-phenylalanine
Peptide Synthesis
Fmoc-Phe(3-CF3)-OH serves as a crucial building block in solid-phase peptide synthesis (SPPS) and solution-phase methods. Its incorporation allows for the introduction of a metabolically stable, trifluoromethylated phenylalanine residue into peptide sequences.
Chemical Biology Research
This compound is employed in chemical biology to create modified peptides or proteins for studying structure-activity relationships. The trifluoromethyl group can act as a useful probe or enhance the lipophilicity and binding characteristics of biomolecules.
Drug Discovery and Development
As an unnatural amino acid derivative, Fmoc-Phe(3-CF3)-OH is valuable in medicinal chemistry for designing novel therapeutic agents. Its incorporation can improve pharmacokinetic properties, such as metabolic stability and cell permeability.
Organic Synthesis
Beyond peptide chemistry, this derivative can be utilised in various organic synthesis pathways where a chiral, fluorinated building block with specific steric and electronic properties is required.
| Molecular weight | 455.43 |
|---|---|
| Empirical formula | C25H20F3NO4 |
| Assay | ≥98.0% (HPLC) |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-Phe(3-CF3)-OH used for?
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Fmoc-Phe(3-CF3)-OH is primarily used as a building block in peptide synthesis, chemical biology research, and drug discovery. It allows for the introduction of a trifluoromethyl-substituted phenylalanine residue into peptides and other molecules to modify their properties.
What are the CAS number and formula for Fmoc-Phe(3-CF3)-OH?
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The CAS number for Fmoc-Phe(3-CF3)-OH is 205526-27-8, and its molecular formula is C25H20F3NO4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-Phe(3-CF3)-OH with a purity of ≥98.0% determined by HPLC. We do not represent this product as USP, BP, EP, or any other pharmacopoeial grade.
How should Fmoc-Phe(3-CF3)-OH be handled and stored?
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Handle Fmoc-Phe(3-CF3)-OH with appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Store the chemical at 2-8°C.
Is Fmoc-Phe(3-CF3)-OH a controlled substance?
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The provided data does not indicate that Fmoc-Phe(3-CF3)-OH is a controlled substance. However, users should always verify compliance with local regulations.
How is Fmoc-Phe(3-CF3)-OH shipped and exported?
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Tech Serve Solutions, a global supplier and exporter, ships and exports chemicals in compliance with international shipping regulations. Please contact us for specific export details and documentation.
How can I request a sample or quote for Fmoc-Phe(3-CF3)-OH?
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To request a sample or quote for Fmoc-Phe(3-CF3)-OH, please visit the Tech Serve Solutions website or contact our sales department directly with your inquiry.
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