Fmoc-pentafluoro-L-phenylalanine
Fmoc-pentafluoro-L-phenylalanine (CAS: 205526-32-5; Formula: C24H16F5NO4) is a specialised unnatural amino acid derivative. With a molecular weight of 477.38, this compound is primarily utilised in chemical biology and peptide chemistry for the synthesis of novel peptides and peptidomimetics. Its unique fluorinated phenyl ring offers distinct properties for research applications, including studies in protein structure and function.
- IUPAC
- (S)-2-(Fmoc-amino)-3-(pentafluorophenyl)propionic acid
Peptide Synthesis
Incorporated into peptide chains to introduce fluorinated aromatic residues, enabling the study of modified protein structures and interactions. Utilised in solid-phase or solution-phase synthesis to create custom peptides with altered physicochemical properties.
Chemical Biology Research
Serves as a building block for constructing modified amino acids and peptides for use in probing biological systems. The pentafluorophenyl group can influence binding affinities and conformational stability in biomolecules.
Drug Discovery and Development
Employed as a synthetic intermediate for developing novel peptidomimetics and small molecules with potential therapeutic applications. The fluorine atoms can enhance metabolic stability and membrane permeability.
Material Science
Explored for its potential in creating novel fluorinated materials and polymers where specific electronic or structural properties are desired. The pentafluorophenyl moiety imparts unique characteristics.
| Molecular weight | 477.38 |
|---|---|
| Empirical formula | C24H16F5NO4 |
| Assay | ≥97% |
| Optical activity | [α]/D -20.5±1.0°, c = 1 in methanol |
| Storage temperature | 2-8°C |
Hazard statements
- H413May cause long-lasting harmful effects to aquatic life
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-pentafluoro-L-phenylalanine used for?
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Fmoc-pentafluoro-L-phenylalanine is used as a building block in peptide synthesis, chemical biology research, and drug discovery, allowing for the introduction of a fluorinated aromatic residue into peptides and peptidomimetics.
What is the CAS number and formula for Fmoc-pentafluoro-L-phenylalanine?
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The CAS number is 205526-32-5, and the empirical formula is C24H16F5NO4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-pentafluoro-L-phenylalanine with an assay of ≥97%. This product is supplied for research and development use and is not guaranteed to be of USP, BP, EP, or other pharmacopoeia grade.
What are the safety and handling recommendations for Fmoc-pentafluoro-L-phenylalanine?
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It is classified with hazard statement H413 (May cause long lasting harmful effects to aquatic life). Recommended personal protective equipment includes eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter. Store at 2-8°C. Handle in a well-ventilated area.
How is Fmoc-pentafluoro-L-phenylalanine packed, shipped, and exported?
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Products are carefully packed according to international shipping regulations. Tech Serve Solutions is an experienced global supplier and exporter of fine chemicals, pharmaceutical intermediates, and laboratory reagents.
How can I request a sample or quote for Fmoc-pentafluoro-L-phenylalanine?
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Please use the 'Request a Quote' or 'Sample Request' form on our website, or contact our customer service team directly with your requirements.
Is Fmoc-pentafluoro-L-phenylalanine a controlled substance?
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Based on the provided data, Fmoc-pentafluoro-L-phenylalanine is not listed as a controlled substance.
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