(1R,2S)-(+)-cis-1-Amino-2-indanol
(1R,2S)-(+)-cis-1-Amino-2-indanol (CAS: 136030-00-7) is a chiral organic compound with the molecular formula C9H11NO. As a vital amino alcohol, it serves as a key building block in asymmetric synthesis, particularly in the development of pharmaceutical intermediates. Its specific stereochemistry makes it valuable for creating complex chiral molecules, contributing to advancements in drug discovery and chemical research.
- IUPAC
- (1R,2S)-(+)-cis-1-Amino-2-hydroxyindane
- Synonyms
- (1R,2S)-(+)-cis-1-Amino-2-hydroxyindane
HIV Protease Inhibitor Synthesis
This cis-aminoindanol and its enantiomer have been instrumental in the synthesis of potent HIV-1 protease inhibitory peptides, advancing research in antiviral therapies.
Chiral Ligands for Asymmetric Reduction
It functions as a chiral ligand in the catalytic asymmetric reduction of prochiral ketones using boranes, enabling stereoselective synthesis of valuable compounds.
Asymmetric Synthesis Intermediate
As a chiral building block, it is employed in various asymmetric synthesis strategies to construct complex stereochemically defined molecules.
Research and Development
Utilised in academic and industrial research laboratories for exploring new synthetic pathways and developing novel chemical entities.
| Molecular weight | 149.19 |
|---|---|
| Empirical formula | C9H11NO |
| Assay | 99% |
| Optical activity | [α]22/D +63°, c = 0.2 in chloroform |
| Optical purity | ee: 99% (GLC) |
| Application | This cis-aminoindanol and its antipode have been used in the preparation of a series of potent HIV-1 protease inhibitory peptides.1,2,3,4,5,6,7,8 Also, they have served as chiral ligands in the catalytic asymmetric reduction of prochiral ketones with boranes.9,10 |
| Melting point | 118-121 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (1R,2S)-(+)-cis-1-Amino-2-indanol primarily used for?
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(1R,2S)-(+)-cis-1-Amino-2-indanol is primarily used in asymmetric synthesis, notably as a building block for HIV protease inhibitors and as a chiral ligand in asymmetric reduction reactions.
What are the CAS number and formula for (1R,2S)-(+)-cis-1-Amino-2-indanol?
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The CAS number is 136030-00-7 and the empirical formula is C9H11NO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (1R,2S)-(+)-cis-1-Amino-2-indanol with an assay of 99%. We do not represent this product as USP, BP, EP, or other pharmacopoeial grades unless explicitly stated.
How should (1R,2S)-(+)-cis-1-Amino-2-indanol be handled safely?
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Handle with appropriate personal protective equipment including a dust mask (N95), eyeshields, and gloves. Avoid inhalation of dust and contact with skin and eyes. Ensure adequate ventilation. This compound is classified as an irritant.
Is this product suitable for export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including (1R,2S)-(+)-cis-1-Amino-2-indanol.
How can I request a sample or a quote?
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Please contact our sales team directly through our website or by phone to request a sample or a formal quotation for (1R,2S)-(+)-cis-1-Amino-2-indanol.
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