Fmoc-tBu-Gly-OH

CAS 132684-60-7C21H23NO4Chemical Synthesis

Fmoc-tBu-Gly-OH (CAS: 132684-60-7) is a protected unnatural amino acid derivative with the empirical formula C21H23NO4 and a molecular weight of 353.41 g/mol. It is a key building block in peptide synthesis, particularly for incorporating tert-leucine residues. This compound finds applications in chemical biology and synthesis, enabling the creation of complex peptides and peptidomimetics. It is supplied by TSS with an assay of ≥98.0%.

IUPAC: Fmoc-L-tert-leucine,Fmoc-Tle-OH
Synonyms: Fmoc-L-tert-leucineFmoc-Tle-OH

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Fmoc-tBu-Gly-OH (C21H23NO4) — chemical structure, CAS 132684-60-7; Chemistry, fine chemical supplied by Tech Serve Solutions

Chemical BiologyChemical SynthesisLeucine DerivativesPeptide Chemistry

01 /Applications

Peptide Synthesis

Fmoc-tBu-Gly-OH serves as a crucial protected amino acid derivative for solid-phase peptide synthesis (SPPS). It facilitates the controlled incorporation of tert-leucine into peptide chains, enabling the study of structure-activity relationships and the development of novel therapeutic peptides.

Chemical Biology

In chemical biology, this compound is utilised for constructing modified peptides and peptidomimetics. These molecules can serve as research tools to probe biological pathways or as potential drug candidates, leveraging the unique properties of the tert-leucine side chain.

Chemical Synthesis

As a versatile building block in organic synthesis, Fmoc-tBu-Gly-OH is employed in the creation of complex molecular architectures. Its protected nature allows for selective chemical transformations, making it valuable for synthesizing non-natural peptides and other advanced organic compounds.

02 /Properties

Molecular weight	353.41
Empirical formula	C21H23NO4
Assay	≥98.0%
Storage temperature	2-8°C
Melting point	124-127 °C

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

132684-60-7

MDL number

MFCD00065649

Beilstein registry

6662856

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Fmoc-tBu-Gly-OH used for?

Fmoc-tBu-Gly-OH is primarily used as a protected building block in peptide synthesis, chemical biology, and organic chemical synthesis for creating peptides containing tert-leucine.

What is the CAS number and formula for Fmoc-tBu-Gly-OH?

The CAS number for Fmoc-tBu-Gly-OH is 132684-60-7, and its empirical formula is C21H23NO4.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Fmoc-tBu-Gly-OH with an assay of ≥98.0%. We do not represent this product as USP, BP, or EP grade.

How should Fmoc-tBu-Gly-OH be handled and stored?

Handle Fmoc-tBu-Gly-OH with appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Store the compound at 2-8°C.