Fmoc-propargyl-Gly-OH
Fmoc-propargyl-Gly-OH (CAS: 198561-07-8), a derivative of glycine with the molecular formula C20H17NO4 and a molecular weight of 335.35 g/mol, is a valuable building block in chemical synthesis. Its structure incorporates an Fmoc protecting group and a propargyl moiety, making it suitable for applications in peptide chemistry and the development of unnatural amino acid derivatives for chemical biology research. This compound is supplied with a purity of ≥98.0% (HPLC).
- IUPAC
- (S)-2-(Fmoc-amino)-4-pentynoic acid,Fmoc-L-2-propargylglycine
- Synonyms
- (S)-2-(Fmoc-amino)-4-pentynoic acidFmoc-L-2-propargylglycine
Peptide Synthesis
Fmoc-propargyl-Gly-OH serves as a key unnatural amino acid building block in solid-phase peptide synthesis. The propargyl group allows for post-translational modification via click chemistry, enabling the creation of complex peptidomimetics and bioconjugates.
Chemical Biology
This compound is utilised in chemical biology for the site-specific labelling of peptides and proteins. Its incorporation allows for the subsequent attachment of reporter molecules, fluorescent probes, or affinity tags using bioorthogonal reactions like the copper-catalyzed azide-alkyne cycloaddition (CuAAC).
Drug Discovery
Fmoc-propargyl-Gly-OH can be employed in the synthesis of novel pharmaceutical intermediates and drug candidates. Its unique structure may confer desirable pharmacokinetic or pharmacodynamic properties to the resulting molecules.
Organic Synthesis
As a versatile reagent, Fmoc-propargyl-Gly-OH finds use in various organic synthesis pathways where the introduction of an Fmoc-protected, alkyne-functionalized glycine residue is required.
| Molecular weight | 335.35 |
|---|---|
| Empirical formula | C20H17NO4 |
| Assay | ≥98.0% (HPLC) |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-propargyl-Gly-OH primarily used for?
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Fmoc-propargyl-Gly-OH is primarily used as a building block in peptide synthesis and chemical biology research, particularly for incorporating unnatural amino acids and enabling post-synthetic modifications via click chemistry.
What are the CAS number and molecular formula for Fmoc-propargyl-Gly-OH?
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The CAS number for Fmoc-propargyl-Gly-OH is 198561-07-8, and its molecular formula is C20H17NO4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-propargyl-Gly-OH with a purity of ≥98.0% (HPLC). This product is not represented as USP, BP, EP, or other pharmacopoeia grades.
How should Fmoc-propargyl-Gly-OH be handled and stored?
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Handle Fmoc-propargyl-Gly-OH with appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter may be required. Store the compound at 2-8°C to maintain its stability.
Is Fmoc-propargyl-Gly-OH classified as a controlled substance?
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The provided data does not indicate that Fmoc-propargyl-Gly-OH is a controlled substance.
How is this chemical packed, shipped, and exported?
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Tech Serve Solutions packs, ships, and exports fine chemicals adhering to international shipping regulations for chemical products, ensuring safe and compliant delivery worldwide.
How can I request a sample or obtain a quote for Fmoc-propargyl-Gly-OH?
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To request a sample or obtain a quote for Fmoc-propargyl-Gly-OH, please contact our sales department through the website or by phone.
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