4-Fluorophenylboronic acid neopentylglycol ester
4-Fluorophenylboronic acid neopentylglycol ester (CAS: 225916-39-2), with the molecular formula C11H14BFO2 and a molecular weight of 208.04 g/mol, is a specialised organoboron compound. It is primarily utilised in organic synthesis as a versatile building block, particularly in cross-coupling reactions like the Suzuki-Miyaura coupling. Its structure facilitates the introduction of the 4-fluorophenyl moiety into complex molecules, making it valuable in the development of pharmaceuticals and advanced materials.
- IUPAC
- 2-(4-Fluorophenyl)-5,5-dimethyl-1,3,2-dioxaborinane
- Synonyms
- 2-(4-Fluorophenyl)-5,5-dimethyl-1,3,2-dioxaborinane
Suzuki-Miyaura Coupling Reagent
This compound serves as a key arylating agent in Suzuki-Miyaura cross-coupling reactions, enabling the formation of carbon-carbon bonds with high selectivity. It is instrumental in synthesising biaryl compounds and complex organic structures.
Pharmaceutical Intermediate Synthesis
The 4-fluorophenyl group is a common motif in many active pharmaceutical ingredients. This ester facilitates its efficient incorporation into drug candidates during medicinal chemistry research and development.
Material Science Applications
It can be employed in the synthesis of organic electronic materials, such as those used in OLEDs or organic photovoltaics, where precise structural control is essential for desired electronic properties.
Organic Synthesis Building Block
Beyond specific named reactions, this boronate ester acts as a versatile synthon for introducing fluorinated phenyl rings into a variety of target molecules across diverse chemical research fields.
| Molecular weight | 208.04 |
|---|---|
| Empirical formula | C11H14BFO2 |
| Assay | 97% |
| Storage temperature | 2-8°C |
| Melting point | 64-68 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Fluorophenylboronic acid neopentylglycol ester used for?
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4-Fluorophenylboronic acid neopentylglycol ester (CAS: 225916-39-2) is primarily used as a building block in organic synthesis, particularly in Suzuki-Miyaura cross-coupling reactions for constructing carbon-carbon bonds and introducing the 4-fluorophenyl group into complex molecules, which is valuable in pharmaceutical and material science research.
What are the CAS number and molecular formula?
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The CAS number for 4-Fluorophenylboronic acid neopentylglycol ester is 225916-39-2, and its molecular formula is C11H14BFO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Fluorophenylboronic acid neopentylglycol ester with an assay of 97%. This product is typically supplied for research and chemical synthesis purposes and is not represented as meeting pharmacopoeia standards (e.g., USP, BP, EP).
How should this chemical be handled?
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This compound is a Warning irritant (H302, H315, H319, H335). Handle with appropriate personal protective equipment including a dust mask (type N95 US), eyeshields, face shields, and gloves. Ensure adequate ventilation and avoid breathing dust. Store at 2-8°C.
Is this product available for export?
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Yes, Tech Serve Solutions specialises in global supply and export of fine chemicals, including 4-Fluorophenylboronic acid neopentylglycol ester, to researchers and industries worldwide.
How can I request a quote or sample?
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To request a quote or a sample of 4-Fluorophenylboronic acid neopentylglycol ester, please visit the Tech Serve Solutions website or contact our sales department directly through the provided contact information.
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