4-Fluorophenylmagnesium bromide solution
4-Fluorophenylmagnesium bromide solution (CAS: 352-13-6) is an organometallic reagent with the linear formula FC₆H₄MgBr and a molecular weight of 199.30 g/mol. Supplied as a 1.0 M solution in Tetrahydrofuran (THF), this flammable liquid is primarily utilised in organic synthesis for introducing the 4-fluorophenyl group into various molecules. Its reactivity makes it a valuable tool in the creation of complex organic structures for research and development.
Grignard Reagent for C-C Bond Formation
4-Fluorophenylmagnesium bromide solution serves as a versatile Grignard reagent in organic synthesis. It readily reacts with electrophiles such as aldehydes, ketones, esters, and epoxides to form new carbon-carbon bonds, facilitating the construction of more complex fluorinated organic compounds.
Synthesis of Fluorinated Pharmaceuticals
The incorporation of fluorine atoms can significantly alter the pharmacokinetic and pharmacodynamic properties of drug molecules. This reagent is employed in the synthesis of intermediates and active pharmaceutical ingredients (APIs) where a 4-fluorophenyl moiety is a key structural feature.
Preparation of Agrochemicals
Fluorinated compounds are also prevalent in the agrochemical industry. 4-Fluorophenylmagnesium bromide solution can be used in the development and production of pesticides, herbicides, and fungicides that benefit from the unique properties imparted by fluorine.
Research and Development Tool
As a specialised organometallic compound, it is indispensable in academic and industrial research laboratories for exploring novel synthetic routes and developing new materials or compounds with specific electronic or physical properties.
| Molecular weight | 199.30 |
|---|---|
| Linear formula | FC6H4MgBr |
| Density | 1.021 g/mL at 25 °C |
| Concentration | 1.0 M in THF |
Hazard statements
- H225Highly flammable liquid and vapour
- H302Harmful if swallowed
- H314Causes severe skin burns and eye damage
- H336May cause drowsiness or dizziness
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | -40 °C / -40 °F |
| Transport (UN / ADR) | UN 2924 8(3) / PGI |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-14-19-22-34-67 |
| Safety statements (S) | 16-26-36/37/39-45 |
| Supplemental hazards | May form explosive peroxides., Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Fluorophenylmagnesium bromide solution used for?
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4-Fluorophenylmagnesium bromide solution is a Grignard reagent used in organic synthesis to introduce the 4-fluorophenyl group into various organic molecules, particularly in the synthesis of fluorinated pharmaceuticals, agrochemicals, and other fine chemicals.
What is the CAS number and formula for 4-Fluorophenylmagnesium bromide solution?
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The CAS number is 352-13-6, and the linear formula is FC₆H₄MgBr.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Fluorophenylmagnesium bromide solution at a concentration of 1.0 M in THF. TSS does not represent this product as USP/BP/EP grade. For specific purity requirements, please contact our sales team.
What are the primary safety hazards associated with 4-Fluorophenylmagnesium bromide solution?
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This product is a highly flammable liquid and vapour (H225). It is harmful if swallowed (H302), causes severe skin burns and eye damage (H314), and may cause drowsiness or dizziness (H336). It reacts violently with water and may form explosive peroxides. Appropriate personal protective equipment, including face shields, gloves, and respiratory protection, must be used. Handle in a well-ventilated area away from ignition sources.
How is 4-Fluorophenylmagnesium bromide solution packed, shipped, and exported?
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4-Fluorophenylmagnesium bromide solution is typically packed in specialised containers suitable for flammable and reactive liquids, adhering to international shipping regulations for hazardous materials. TSS is experienced in exporting chemicals globally.
How can I request a quote or sample for 4-Fluorophenylmagnesium bromide solution?
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To request a quote or a sample, please contact our sales department via the website or by phone, providing the product name (4-Fluorophenylmagnesium bromide solution) and CAS number (352-13-6).
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