4-Fluorophenylzinc bromide solution
4-Fluorophenylzinc bromide solution (CAS: 181705-93-1), with the linear formula FC<sub>6</sub>H<sub>4</sub>ZnBr and a molecular weight of 240.39 g/mol, is a valuable organozinc reagent. Supplied as a 0.5 M solution in THF, it is primarily utilised in organic synthesis for carbon-carbon bond formation. Its reactive nature makes it instrumental in cross-coupling reactions, offering a controlled method for introducing the 4-fluorophenyl moiety into complex molecules within pharmaceutical and fine chemical research and development.
Organometallic Cross-Coupling Reactions
4-Fluorophenylzinc bromide is a key reagent in palladium-catalysed cross-coupling reactions, such as Negishi couplings. It enables the formation of new carbon-carbon bonds by coupling the 4-fluorophenyl group with various organic halides or pseudohalides.
Synthesis of Fluorinated Pharmaceuticals
The incorporation of fluorine atoms can significantly alter the pharmacokinetic properties of drug candidates. This reagent facilitates the introduction of the 4-fluorophenyl group, a common motif in many pharmaceuticals, contributing to the synthesis of novel therapeutics.
Preparation of Fine Chemicals and Advanced Materials
Beyond pharmaceuticals, this organozinc compound serves as a versatile building block in the synthesis of other complex organic molecules and advanced materials where precise fluorophenyl substitution is required.
| Molecular weight | 240.39 |
|---|---|
| Linear formula | FC6H4ZnBr |
| Density | 0.992 g/mL at 25 °C |
| Concentration | 0.5 M in THF |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P281Use personal protective equipment as required
- P305IF IN EYES
| Flash point | -17 °C / 1.4 °F |
|---|---|
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xn |
| Risk statements (R) | 11-14-19-36/37-40 |
| Safety statements (S) | 16-26-36/37 |
| Supplemental hazards | May form explosive peroxides. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Fluorophenylzinc bromide solution used for?
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4-Fluorophenylzinc bromide solution (CAS: 181705-93-1) is primarily used in organic synthesis, particularly for carbon-carbon bond formation via cross-coupling reactions like the Negishi coupling. It is instrumental in introducing the 4-fluorophenyl group into organic molecules for the synthesis of pharmaceuticals and fine chemicals.
What are the CAS number and formula for this product?
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The CAS number is 181705-93-1, and the linear formula is FC<sub>6</sub>H<sub>4</sub>ZnBr.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Fluorophenylzinc bromide solution at a concentration of 0.5 M in THF. This is a technical or research grade product and is not represented as USP, BP, or EP.
How should 4-Fluorophenylzinc bromide solution be handled and stored?
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This solution is highly flammable (H225) and can cause serious eye irritation (H319), respiratory irritation (H335), and is suspected of causing cancer (H351). It may also form explosive peroxides. Handle in a well-ventilated area, away from ignition sources, and wear appropriate personal protective equipment. Store refrigerated at 2-8°C, as indicated by the storage temperature.
Is 4-Fluorophenylzinc bromide solution a controlled substance?
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The provided data does not indicate that 4-Fluorophenylzinc bromide solution is a controlled substance.
How is this chemical shipped and exported?
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4-Fluorophenylzinc bromide solution is shipped as UN 2924, Hazard Class 8 (3), Packing Group II. Tech Serve Solutions is experienced in exporting chemicals globally, adhering to all relevant transportation regulations.
How can I request a sample or quote for 4-Fluorophenylzinc bromide solution?
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To request a sample or a quote for 4-Fluorophenylzinc bromide solution, please use the contact form on our website or contact our sales team directly.
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