4-Fluorophenylacetyl chloride
4-Fluorophenylacetyl chloride (CAS 459-04-1) is a fluorinated organic building block with the linear formula FC6H4CH2COCl and a molecular weight of 172.58 g/mol. This acid halide serves as a useful intermediate in pharmaceutical synthesis, contributing to the development of advanced chemical entities. Its properties make it suitable for various organic synthesis applications, particularly where fluorinated aromatic moieties are required.
Pharmaceutical Intermediate
4-Fluorophenylacetyl chloride is recognised as a valuable intermediate in the synthesis of pharmaceutical compounds. Its structure facilitates the introduction of a fluorinated phenylacetyl group into more complex molecules, aiding in the development of novel drug candidates.
Organic Synthesis
As a reactive acid halide, this compound is employed in diverse organic synthesis pathways. It readily participates in acylation reactions, making it a versatile building block for creating a range of organic compounds.
Fluorinated Building Block
The presence of the fluorine atom on the phenyl ring makes 4-Fluorophenylacetyl chloride a key component for introducing fluorinated aromatic structures. This is important in medicinal chemistry and materials science where fluorine substitution can significantly alter molecular properties.
| Molecular weight | 172.58 |
|---|---|
| Linear formula | FC6H4CH2COCl |
| Assay | 97% |
| Boiling point | 60 °C/8 mmHg(lit.) |
| Density | 1.259 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.512(lit.) |
| Storage temperature | 2-8°C |
| Application | A useful pharmaceutical intermediate.1,2,3 |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Flash point | 107 °C / 224.6 °F |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-27-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Fluorophenylacetyl chloride used for?
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4-Fluorophenylacetyl chloride (CAS 459-04-1) is primarily used as a pharmaceutical intermediate and a building block in organic synthesis, particularly for introducing fluorinated aromatic moieties.
What is the CAS number and formula for 4-Fluorophenylacetyl chloride?
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The CAS number for 4-Fluorophenylacetyl chloride is 459-04-1, and its linear formula is FC6H4CH2COCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Fluorophenylacetyl chloride with a minimum assay of 97%. TSS does not represent this product as USP, BP, EP, or other pharmacopoeia grades unless explicitly stated in the product data.
How should 4-Fluorophenylacetyl chloride be handled safely?
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4-Fluorophenylacetyl chloride is classified as Danger (GHS05) and causes severe skin burns and eye damage (H314). Appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection, is essential. Handle in a well-ventilated area, following strict safety protocols.
How is 4-Fluorophenylacetyl chloride typically packed and exported?
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4-Fluorophenylacetyl chloride is typically packed in accordance with UN 3265, Class 8, Packing Group II regulations for safe transport. TSS exports chemicals globally, adhering to all relevant international shipping and handling standards.
How can I request a quote or sample for 4-Fluorophenylacetyl chloride?
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To request a quote or a sample of 4-Fluorophenylacetyl chloride, please contact our sales team through the website or via direct inquiry. Please provide your contact details and intended use for prompt service.
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