2,5-Difluorobenzylzinc bromide solution
2,5-Difluorobenzylzinc bromide solution (CAS: 307496-32-8) is an organozinc halide supplied by Tech Serve Solutions. With a molecular weight of 272.41 g/mol, this reagent is prepared as a 0.5 M solution in Tetrahydrofuran (THF) and stored under refrigeration. It serves as a valuable building block in organic synthesis, particularly for introducing the 2,5-difluorobenzyl group into molecules through cross-coupling reactions.
- Synonyms
- F2C6H3CH2ZnBr
Organometallic Synthesis
As an organozinc halide, it participates in various transition-metal catalysed cross-coupling reactions, such as Negishi couplings. This enables the formation of new carbon-carbon bonds for complex molecule construction.
Pharmaceutical Intermediate Synthesis
The 2,5-difluorobenzyl moiety is found in various biologically active compounds. This reagent provides a direct route for incorporating this specific fluorinated benzyl group during the synthesis of potential drug candidates.
Materials Science
Fluorinated organic compounds are increasingly utilised in materials science due to their unique electronic and physical properties. This reagent can be employed in the synthesis of novel fluorinated organic materials.
| Molecular weight | 272.41 |
|---|---|
| Linear formula | F2C6H3CH2ZnBr |
| Density | 0.993 g/mL at 25 °C |
| Concentration | 0.5 M in THF |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P281Use personal protective equipment as required
- P305IF IN EYES
| Flash point | -17 °C / 1.4 °F |
|---|---|
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xn |
| Risk statements (R) | 11-14-19-36/37-40 |
| Safety statements (S) | 16-26-36/37 |
| Supplemental hazards | May form explosive peroxides. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,5-Difluorobenzylzinc bromide solution used for?
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2,5-Difluorobenzylzinc bromide solution is primarily used as a reagent in organic synthesis for the introduction of the 2,5-difluorobenzyl group, especially in cross-coupling reactions like Negishi coupling, facilitating the synthesis of complex organic molecules, pharmaceutical intermediates, and advanced materials.
What is the CAS number and formula for 2,5-Difluorobenzylzinc bromide solution?
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The CAS number is 307496-32-8 and the linear formula is F2C6H3CH2ZnBr.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2,5-Difluorobenzylzinc bromide solution at a concentration of 0.5 M in THF. The specific purity assay is available upon request, and TSS does not represent this product as USP/BP/EP or any other pharmacopoeial grade.
How should 2,5-Difluorobenzylzinc bromide solution be handled and stored?
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This is a highly flammable liquid and vapour (H225), causes serious eye irritation (H319), and may cause respiratory irritation (H335). It may also be suspected of causing cancer (H351) and may form explosive peroxides. Handle in a well-ventilated area, away from ignition sources, wearing appropriate personal protective equipment. Store at 2-8°C.
Is 2,5-Difluorobenzylzinc bromide solution shipped internationally?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 2,5-Difluorobenzylzinc bromide solution, and can arrange for export worldwide.
How can I request a quote or sample for 2,5-Difluorobenzylzinc bromide solution?
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To request a quote or sample, please contact our sales team through the website or by phone, providing the product name and CAS number (307496-32-8).
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