2,5-Difluorobenzyl bromide
2,5-Difluorobenzyl bromide (CAS: 85117-99-3), with the molecular formula F₂C₆H₃CH₂Br and a molecular weight of 207.02 g/mol, is a fluorinated aromatic building block. It serves as a key intermediate in organic synthesis. This compound has been utilised in the development of novel therapeutic agents, including potential treatments for Alzheimer's disease, and in the creation of various sulfonamide and amide derivatives, underscoring its utility in pharmaceutical research and chemical manufacturing.
- IUPAC
- α-Bromo-2,5-difluorotoluene
- Synonyms
- F2C6H3CH2Brα-Bromo-2,5-difluorotoluene
Synthesis of γ-Secretase Inhibitors
2,5-Difluorobenzyl bromide has been employed in the synthesis of novel series of cyclohexanone-derived γ-secretase inhibitors. These compounds are being investigated for their potential in treating Alzheimer's disease.
Preparation of Sulfonamide Derivatives
This reagent is used in the preparation of various sulfonamide derivatives. Its reactivity allows for the incorporation of the 2,5-difluorobenzyl moiety into diverse chemical structures for further research.
Synthesis of Amide and Amine Derivatives
The compound facilitates the synthesis of amide and acyclic amine derivatives. These syntheses leverage the benzyl bromide functionality for nucleophilic substitution reactions.
| Molecular weight | 207.02 |
|---|---|
| Linear formula | F2C6H3CH2Br |
| Assay | 98% |
| Density | 1.609 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.526(lit.) |
| Application | 2,5-Difluorobenzyl bromide has been used in the synthesis of:• novel series of 4-aryl, 4-phenylsulfonyl cyclohexananone-derived γ-secretase inhibitors, for the potential treatment of Alzheimer′s disease1• sulfonamide, amide and acyclic amine derivatives2 |
Hazard statements
- H225Highly flammable liquid and vapour
- H314Causes severe skin burns and eye damage
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 16 °C / 60.8 °F |
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,5-Difluorobenzyl bromide used for?
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2,5-Difluorobenzyl bromide is used as a building block in organic synthesis, particularly in the preparation of novel therapeutic agents like γ-secretase inhibitors for Alzheimer's disease and various sulfonamide, amide, and amine derivatives.
What are the CAS number and molecular formula for 2,5-Difluorobenzyl bromide?
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The CAS number for 2,5-Difluorobenzyl bromide is 85117-99-3, and its molecular formula is F₂C₆H₃CH₂Br.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2,5-Difluorobenzyl bromide with an assay of 98%. This product is not represented as USP, BP, EP, or pharmaceutical grade unless explicitly stated.
How should 2,5-Difluorobenzyl bromide be handled safely?
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2,5-Difluorobenzyl bromide is a dangerous substance (Danger) that is highly flammable (H225) and causes severe skin burns and eye damage (H314). Appropriate personal protective equipment, including full-face respirators, gloves, and goggles, must be used, and handling should occur in a well-ventilated area away from ignition sources.
Is 2,5-Difluorobenzyl bromide exported by Tech Serve Solutions?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 2,5-Difluorobenzyl bromide.
How can I request a quote or sample for 2,5-Difluorobenzyl bromide?
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To request a quote or sample for 2,5-Difluorobenzyl bromide, please contact the Tech Serve Solutions sales team through the website or direct inquiry channels.
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