2,5-Difluorobenzoyl chloride
2,5-Difluorobenzoyl chloride (CAS: 35730-09-7) is a fluorinated aromatic acid halide with the linear formula F₂C₆H₃COCl and a molecular weight of 176.55 g/mol. This reactive compound is primarily utilised as a building block in organic synthesis. Its key applications include its use in the preparation of ethyl 4-(2′,5′-difluorobenzoyl)-3,5-dimethyl-1H-pyrrole-2-carboxylate and various thiohydrazides, contributing to the development of novel chemical entities.
- Synonyms
- F2C6H3COCl
Synthesis of Pyrrole Derivatives
2,5-Difluorobenzoyl chloride is employed in the synthesis of complex heterocyclic compounds, such as ethyl 4-(2′,5′-difluorobenzoyl)-3,5-dimethyl-1H-pyrrole-2-carboxylate. This demonstrates its utility in creating advanced organic molecules for research.
Preparation of Thiohydrazides
The compound serves as a precursor in the formation of thiohydrazides. This application highlights its role as a versatile reagent in the synthesis of sulphur-containing organic compounds.
Fluorinated Building Block
As a difluorinated benzoyl chloride, it functions as a valuable building block in medicinal chemistry and materials science, enabling the introduction of fluorinated aromatic moieties into larger structures.
| Molecular weight | 176.55 |
|---|---|
| Linear formula | F2C6H3COCl |
| Assay | 98% |
| Boiling point | 92-93 °C/34 mmHg(lit.) |
| Density | 1.425 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.515(lit.) |
| Application | 2,5-Difluorobenzoyl chloride has been used in the synthesis of:• ethyl 4-(2′,5′-difluorobenzoyl)-3,5-dimethyl-1H-pyrrole-2-carboxylate (JJ78:1)1• thiohydrazide2 |
Hazard statements
- H226Flammable liquid and vapour
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 59 °C / 138.2 °F |
| Transport (UN / ADR) | UN 2920 3(8) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,5-Difluorobenzoyl chloride used for?
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2,5-Difluorobenzoyl chloride is used as a building block in organic synthesis, notably in the preparation of ethyl 4-(2′,5′-difluorobenzoyl)-3,5-dimethyl-1H-pyrrole-2-carboxylate and thiohydrazides.
What are the CAS number and chemical formula for 2,5-Difluorobenzoyl chloride?
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The CAS number is 35730-09-7, and the linear formula is F₂C₆H₃COCl.
What grade and purity does Tech Serve Solutions supply for 2,5-Difluorobenzoyl chloride?
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Tech Serve Solutions supplies 2,5-Difluorobenzoyl chloride with an assay of 98%. We do not represent this product as USP, BP, or EP grade.
How should 2,5-Difluorobenzoyl chloride be handled safely?
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2,5-Difluorobenzoyl chloride is a corrosive and flammable liquid (Danger, H226-H314). Handle with appropriate personal protective equipment, including gloves, goggles, and a full-face respirator, in a well-ventilated area. Ensure compliance with safety statements P280, P305 + P351 + P338, and P310.
Is 2,5-Difluorobenzoyl chloride shipped internationally?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 2,5-Difluorobenzoyl chloride.
How can I request a quote or sample for 2,5-Difluorobenzoyl chloride?
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Please contact our sales team directly via our website or by phone to request a quote or sample of 2,5-Difluorobenzoyl chloride.
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