2,5-Difluoronitrobenzene
2,5-Difluoronitrobenzene (CAS: 364-74-9) is an organic compound with the molecular formula C6H3F2NO2 and a molecular weight of 159.09 g/mol. This fluorinated nitroaromatic serves as a valuable building block in organic synthesis. It is primarily utilized in the preparation of various heterocyclic compounds, contributing to advancements in materials science and pharmaceutical research.
- IUPAC
- 1,4-Difluoro-2-nitrobenzene
- Synonyms
- F2C6H3NO21,4-Difluoro-2-nitrobenzene
Synthesis of N-Alkylated 2-Arylaminobenzimidazoles
2,5-Difluoronitrobenzene is a key intermediate in the synthesis of N-alkylated 2-arylaminobenzimidazoles. This application is relevant for the development of novel chemical entities with potential biological activities.
Preparation of Quinoxalinones
The compound finds application in the preparation of quinoxalinone derivatives. These structures are of interest in medicinal chemistry and the synthesis of functional materials.
Intermediate for Isoquinoline Derivatives
It serves as a precursor for the synthesis of N-(2-nitro-4-fluorophenyl)-1,2,3,4-tetrahydroisoquinoline. This highlights its utility in constructing complex nitrogen-containing heterocyclic systems.
| Molecular weight | 159.09 |
|---|---|
| Linear formula | F2C6H3NO2 |
| Assay | 97% |
| Boiling point | 206.5 °C(lit.) |
| Density | 1.467 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.509(lit.) |
| Application | 2,5-Difluoronitrobenzene was used in the synthesis of :• N-alkylated 2-arylaminobenzimidazoles1• quinoxalinones2• N-(2-nitro-4-fluorophenyl)-l,2,3,4-tetrahydroisoquinoline3 |
| Melting point | −11.7 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 90 °C / 194 °F |
| Transport (UN / ADR) | NA 1993 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,5-Difluoronitrobenzene used for?
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2,5-Difluoronitrobenzene is used as a building block in organic synthesis, particularly for preparing N-alkylated 2-arylaminobenzimidazoles, quinoxalinones, and N-(2-nitro-4-fluorophenyl)-1,2,3,4-tetrahydroisoquinoline.
What are the CAS number and formula for 2,5-Difluoronitrobenzene?
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The CAS number is 364-74-9 and the formula is C6H3F2NO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2,5-Difluoronitrobenzene with an assay of 97%. This is a technical/research grade material and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should 2,5-Difluoronitrobenzene be handled safely?
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2,5-Difluoronitrobenzene is a Warning chemical that causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). It requires handling with appropriate personal protective equipment, including eyeshields, gloves, and suitable respiratory protection.
Is 2,5-Difluoronitrobenzene available for export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 2,5-Difluoronitrobenzene.
How can I request a quote or sample?
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To request a quote or sample of 2,5-Difluoronitrobenzene, please contact our sales team through the website or by phone.
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