Rp-8-Bromo-β-phenyl-1,N2-ethenoguanosine 3′,5′-cyclic monophosphorothioate sodium salt
Rp-8-Bromo-β-phenyl-1,N2-ethenoguanosine 3′,5′-cyclic monophosphorothioate sodium salt (CAS: 185246-32-6) is a guanylyl cyclase inhibitor with the empirical formula C18H14BrN5NaO6PS and a molecular weight of 562.27 g/mol. This white to beige powder is primarily used in biochemical research as a tool for studying cell signaling pathways, particularly those involving cyclic nucleotides and protein kinase A. Its specific inhibitory action makes it valuable for investigating guanylyl cyclase activity in various biological contexts.
- IUPAC
- Rp-β-Phenyl-1,N2-etheno-8-bromoguanosine 3′,5′-cyclic monophosphorothioate sodium salt,Rp-8-Br-PET-cGMPS
- Synonyms
- 185246-32-6C18H14BrN5NaO6PSRp-β-Phenyl-1,N2-etheno-8-bromoguanosine 3′,5′-cyclic monophosphorothioate sodium saltRp-8-Br-PET-cGMPS
Cell Signaling Research
Serves as a research tool to investigate the role of guanylyl cyclase in cellular signal transduction pathways. Its inhibitory properties aid in understanding the downstream effects of cyclic nucleotide metabolism.
Enzyme Inhibition Studies
Utilised in studies focusing on enzyme inhibitors, specifically targeting guanylyl cyclase. Researchers employ this compound to probe the mechanisms and regulation of this critical enzyme.
Neuroscience Research
Applied in neuroscience research to explore the involvement of cyclic nucleotide signaling pathways in neuronal function and dysfunction.
Biochemical Assays
Incorporated into biochemical assays to modulate or block guanylyl cyclase activity, enabling the study of related enzymatic processes and cellular responses.
| Molecular weight | 562.27 |
|---|---|
| Empirical formula | C18H14BrN5NaO6PS |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Colour | white to beige |
| Solubility | H2O: soluble15 mg/mL at ≤60 °C |
| Storage temperature | −20°C |
| Melting point | 240-300 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Rp-8-Bromo-β-phenyl-1,N2-ethenoguanosine 3′,5′-cyclic monophosphorothioate sodium salt used for?
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This compound is primarily used as a guanylyl cyclase inhibitor in biochemical and cell signaling research. It is valuable for studying cyclic nucleotide metabolism and related pathways, including those involving protein kinase A and G proteins.
What are the CAS number and empirical formula for this product?
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The CAS number is 185246-32-6 and the empirical formula is C18H14BrN5NaO6PS.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product with an assay of ≥98% by HPLC. This is a research-grade chemical and is not represented as USP, BP, EP, or pharmaceutical grade.
How should Rp-8-Bromo-β-phenyl-1,N2-ethenoguanosine 3′,5′-cyclic monophosphorothioate sodium salt be handled and stored?
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Handle with appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter. Store at -20°C. The material is classified under WGK Germany 3, indicating it is hazardous to water.
How is this chemical shipped and exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, and this product can be shipped and exported worldwide according to all applicable regulations.
How can I request a quote or sample?
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Please contact our sales team via the website or provide your details to request a quote or sample of Rp-8-Bromo-β-phenyl-1,N2-ethenoguanosine 3′,5′-cyclic monophosphorothioate sodium salt.
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