GGTI 298 trifluoroacetate salt hydrate
GGTI 298 trifluoroacetate salt hydrate (CAS: 1217457-86-7) is a chemical compound with the formula C27H33N3O3S · C2HF3O2 · xH2O. This lyophilized, colourless substance, weighing 593.66 g/mol (anhydrous basis), functions as a potent inhibitor of geranylgeranyl transferase I. It is primarily utilised in biochemical research, cancer metabolism studies, and cell biology investigations to explore cellular pathways.
- IUPAC
- N-[[4-(2-(R)-Amino-3-mercaptopropyl)amino]-2-naphthylbenzoyl]leucine methyl ester trifluoroacetate salt hydrate
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Geranylgeranyl Transferase I Inhibition
GGTI 298 trifluoroacetate salt hydrate acts as an inhibitor of geranylgeranyl transferase I (PGGT1B). This enzyme is crucial for the post-translational modification of proteins, influencing their localisation and function.
Cancer Research
This compound is employed in studies investigating cancer metabolism and the mevalonate pathway. By inhibiting geranylgeranyl transferase, it can help elucidate the roles of prenylated proteins in cancer cell proliferation and survival.
Cell Biology Studies
As a bioactive small molecule, GGTI 298 is valuable for cell biology research. It can be used to probe the effects of protein prenylation disruption on various cellular processes and signalling pathways.
| Molecular weight | 593.66 (anhydrous basis) |
|---|---|
| Empirical formula | C27H33N3O3S · C2HF3O2 · xH2O |
| Assay | ≥90% (HPLC) |
| Form | filmlyophilized |
| Colour | colorless |
| Solubility | DMSO: >20 mg/mL |
| Storage temperature | −20°C |
| Melting point | 99.5-100 °C |
| Impurities tested | <10% dimer |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... PGGT1B(5229) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is GGTI 298 trifluoroacetate salt hydrate used for?
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GGTI 298 trifluoroacetate salt hydrate is primarily used as an inhibitor of geranylgeranyl transferase I in research settings, particularly in cancer metabolism, cancer research, and cell biology studies.
What are the CAS number and formula for GGTI 298 trifluoroacetate salt hydrate?
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The CAS number for the anhydrous form is 1217457-86-7. The empirical formula is C27H33N3O3S · C2HF3O2 · xH2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies GGTI 298 trifluoroacetate salt hydrate with an assay of ≥90% (HPLC). We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety considerations when handling GGTI 298 trifluoroacetate salt hydrate?
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This compound is classified as a GHS07 warning. It causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (type N95), eyeshields, and gloves, should be used. Handle in a well-ventilated area.
How is GGTI 298 trifluoroacetate salt hydrate shipped and exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including GGTI 298 trifluoroacetate salt hydrate, ensuring appropriate packaging and adherence to international shipping regulations.
How can I request a quote or sample for GGTI 298 trifluoroacetate salt hydrate?
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Please contact our sales team via our website or direct inquiry to request a quotation or a sample of GGTI 298 trifluoroacetate salt hydrate.
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