GBR 12909 dihydrochloride
GBR 12909 dihydrochloride (CAS 67469-78-7) is a white, solid chemical compound with the molecular formula C28H32F2N2O · 2HCl. This selective dopamine D2 receptor antagonist and D1/D5 receptor agonist is a valuable tool in neuroscience research. It is primarily utilised for its ability to modulate dopaminergic pathways, aiding in the study of neurodegenerative diseases, psychiatric disorders, and the mechanisms of neurotransmission.
- IUPAC
- 1-(2-[bis(4-Fluorophenyl)methoxy]ethyl)-4-(3-phenylpropyl)piperazine dihydrochloride
Dopamine Receptor Research
GBR 12909 dihydrochloride serves as a selective antagonist for the dopamine D2 receptor and an agonist for D1 and D5 receptors. This makes it instrumental in investigating dopaminergic system function and associated neurological processes.
Neuroscience Investigations
This compound is employed to study the intricate mechanisms of neurotransmission and the role of dopamine in various brain functions. Its selectivity aids in dissecting specific receptor pathways involved in normal and pathological conditions.
Pharmacological Tool
Researchers utilise GBR 12909 dihydrochloride as a pharmacological tool to explore potential therapeutic targets in disorders related to dopamine dysregulation, such as Parkinson's disease and schizophrenia.
| Molecular weight | 523.49 |
|---|---|
| Empirical formula | C28H32F2N2O · 2HCl |
| Assay | ≥98% (HPLC) |
| Form | solid |
| Colour | white |
| Solubility | DMSO: >5 mg/mL (Solutions freshly prepared daily) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is GBR 12909 dihydrochloride used for?
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GBR 12909 dihydrochloride is used in neuroscience research as a selective dopamine D2 receptor antagonist and D1/D5 receptor agonist to study dopaminergic pathways and neurotransmission.
What are the CAS number and formula for GBR 12909 dihydrochloride?
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The CAS number is 67469-78-7 and the formula is C28H32F2N2O · 2HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies GBR 12909 dihydrochloride with a purity of ≥98% (HPLC). We do not represent this product as USP, BP, or EP grade.
What are the safety and handling considerations for GBR 12909 dihydrochloride?
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Handling requires appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter. The compound is classified with WGK Germany 3.
How is GBR 12909 dihydrochloride packed and shipped?
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GBR 12909 dihydrochloride is typically supplied as a solid. Specific packaging and shipping details for export are available upon request, adhering to all relevant regulations.
How can I request a quote or sample for GBR 12909 dihydrochloride?
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To request a quote or sample, please contact our sales team through the website or directly via email or phone, providing the product name and CAS number.
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