1-(4-Hydroxyphenyl)-1H-tetrazole-5-thiol
1-(4-Hydroxyphenyl)-1H-tetrazole-5-thiol (CAS 52431-78-4) is a heterocyclic building block with the molecular formula C7H6N4OS and a molar mass of 194.21 g/mol. It is a crystalline tetrazole-5-thiol bearing a 4-hydroxyphenyl substituent, combining an acidic thiol/thione tautomer with a phenolic hydroxyl. Tech Serve Solutions supplies it as a research-grade reagent for organic and pharmaceutical synthesis, where it serves as a sulphur-containing intermediate and ligand. It melts at about 170 °C with decomposition.
- Synonyms
- 1-(4-Hydroxyphenyl)-1H-tetrazole-5-thiol1-(4-Hydroxyphenyl)-5-mercaptotetrazole5-Mercapto-1-(4-hydroxyphenyl)tetrazole4-(5-Mercapto-1H-tetrazol-1-yl)phenol1-(4-Hydroxyphenyl)-1H-tetrazole-5(4H)-thioneCAS 52431-78-4
Heterocyclic building block
Used as a tetrazole-5-thiol scaffold in chemical synthesis, providing both an acidic thiol and a phenolic handle for further functionalisation. It supports the construction of more complex nitrogen- and sulphur-containing molecules.
Pharmaceutical intermediate
Serves as an intermediate in pharmaceutical and medicinal chemistry research. The 1-aryl-tetrazole-5-thiol motif is a recognised structural element in active-pharmaceutical-ingredient synthesis.
Thioether and S-alkylation chemistry
The thiol group is readily S-alkylated or S-arylated to form tetrazolyl thioethers and related derivatives. This makes the compound a convenient sulphur donor for building thio-linked structures.
Coordination and ligand studies
Tetrazole-5-thiols can act as ligands through their nitrogen and sulphur donor atoms. The compound is suitable for laboratory studies of metal coordination and related materials chemistry.
Research and reference reagent
Supplied for laboratory-scale synthesis, method development and analytical reference use. Its defined identity (CAS 52431-78-4, MDL MFCD00132898) supports reproducible experimental work.
| Molecular weight | 194.21 |
|---|---|
| Empirical formula | C7H6N4OS |
| Melting point | 170 °C (dec.)(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(4-Hydroxyphenyl)-1H-tetrazole-5-thiol used for?
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It is used mainly as a heterocyclic building block and intermediate in organic and pharmaceutical synthesis. The tetrazole-5-thiol core and 4-hydroxyphenyl group make it useful for S-alkylation chemistry, the preparation of tetrazolyl thioethers, and laboratory ligand and coordination studies.
What is the CAS number and molecular formula of 1-(4-Hydroxyphenyl)-1H-tetrazole-5-thiol?
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Its CAS number is 52431-78-4 and its molecular formula is C7H6N4OS, with a molecular weight of 194.21 g/mol. Additional identifiers include EC number 257-909-2, MDL number MFCD00132898 and PubChem substance ID 24895782.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound as a technical/research-grade reagent intended for synthesis and laboratory use. We do not represent it as USP, BP or EP pharmacopoeia grade. A current specification and certificate of analysis, including the assay for each lot, are provided on request.
What are the safety and handling precautions for this compound?
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It is classified under GHS07 with the signal word Warning. The hazard statements are H315 (causes skin irritation), H319 (causes serious eye irritation) and H335 (may cause respiratory irritation). Avoid breathing dust, wear gloves and eye protection, and follow the precautionary advice P261 and P305+P351+P338. It is assigned WGK 2 (water-hazard class) in Germany. Always consult the Safety Data Sheet before use.
How is 1-(4-Hydroxyphenyl)-1H-tetrazole-5-thiol packed, shipped and exported?
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It is packed in tightly closed, appropriately labelled containers sized from research quantities to bulk, with packaging selected to protect the material in transit. Tech Serve Solutions ships and exports worldwide, supplying the Safety Data Sheet, certificate of analysis and required export documentation with each consignment.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, packing preference and destination, and our team will respond with availability, lead time and documentation. Sample and bulk enquiries for CAS 52431-78-4 are both welcome.
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