Fmoc-Thr(tBu)-OH
Fmoc-Thr(tBu)-OH (CAS 71989-35-0), with the molecular formula C23H27NO5, is a tert-butyl-protected Fmoc derivative of L-threonine. This amino acid derivative is a crucial building block in solid-phase peptide synthesis (SPPS), facilitating the incorporation of threonine residues with protected hydroxyl and amine groups. Its application is essential for the construction of complex peptides and peptidomimetics in chemical biology and drug discovery.
- IUPAC
- Fmoc-O-tert-butyl-L-threonine
- Synonyms
- Fmoc-O-tert-butyl-L-threonine
Peptide Synthesis
Fmoc-Thr(tBu)-OH is widely used in solid-phase peptide synthesis (SPPS) as a protected threonine building block. The Fmoc group allows for orthogonal protection strategies, while the tert-butyl group protects the threonine side chain hydroxyl during synthesis.
Chemical Biology Research
This compound serves as a key reagent in the synthesis of peptides for various chemical biology applications, including the study of protein structure-function relationships and the development of peptide-based therapeutics.
Drug Discovery
It is employed in the creation of novel peptide libraries and peptidomimetics as potential drug candidates. The precise incorporation of modified amino acids like this one is vital for optimising pharmacological properties.
| Molecular weight | 397.46 |
|---|---|
| Empirical formula | C23H27NO5 |
| Assay | ≥98.0% (HPLC) |
| Optical activity | [α]20/D +16±1°, c = 1% in ethyl acetate |
| Storage temperature | 2-8°C |
Hazard statements
- H410Very toxic to aquatic life with long-lasting effects
Precautionary statements
- P273Avoid release to the environment
- P501Dispose of contents and container per local regulations
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Transport (UN / ADR) | UN 3077 9 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | N |
| Risk statements (R) | 50/53 |
| Safety statements (S) | 60-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-Thr(tBu)-OH used for?
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Fmoc-Thr(tBu)-OH is primarily used as a protected amino acid building block in solid-phase peptide synthesis (SPPS) for constructing peptides containing threonine residues.
What is the CAS number and formula for Fmoc-Thr(tBu)-OH?
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The CAS number for Fmoc-Thr(tBu)-OH is 71989-35-0, and its molecular formula is C23H27NO5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-Thr(tBu)-OH with an assay of ≥98.0% (HPLC). We do not represent this product as USP, BP, or EP grade.
How should Fmoc-Thr(tBu)-OH be handled and stored?
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Handle Fmoc-Thr(tBu)-OH with appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator filter (type N95 or P1). It should be stored at 2-8°C.
Is Fmoc-Thr(tBu)-OH environmentally hazardous?
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Yes, Fmoc-Thr(tBu)-OH is classified as hazardous to the aquatic environment with long-lasting effects (H410). Prevent release to the environment.
How can I request a quote or sample for Fmoc-Thr(tBu)-OH?
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To request a quote or sample, please contact our sales team through our website or by phone. We are a global supplier, exporter, and manufacturer of fine chemicals.
How is Fmoc-Thr(tBu)-OH packed and shipped?
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Fmoc-Thr(tBu)-OH is packed according to UN 3077, 9 / PGIII regulations for safe transport. We export globally, ensuring compliance with all shipping requirements.
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