2,5-Difluorophenylboronic acid
2,5-Difluorophenylboronic acid (CAS 193353-34-3) is an organoboron compound with the formula F2C6H3B(OH)2 and a molar mass of 157.91 g/mol. This aryl boronic acid derivative serves as a valuable building block in organic synthesis. It is particularly employed as a reactant in Suzuki-Miyaura cross-coupling reactions and in the preparation of specific bioactive molecules, such as sphingosine phosphate receptor antagonists.
- IUPAC
- 2,5-Difluorobenzeneboronic acid
- Synonyms
- F2C6H3B(OH)22,5-Difluorobenzeneboronic acid
Suzuki-Miyaura Cross-Coupling Reactions
2,5-Difluorophenylboronic acid is a key reagent in Suzuki-Miyaura cross-coupling reactions. This palladium-catalyzed process is widely used for the formation of carbon-carbon bonds, enabling the synthesis of complex biaryl compounds.
Preparation of Bioactive Compounds
This compound is utilized in the synthesis of specialised molecules. It has been employed in the preparation of selective sphingosine phosphate receptor antagonists, contributing to medicinal chemistry research.
Organic Synthesis Intermediate
As an aryl boronic acid, 2,5-Difluorophenylboronic acid acts as a versatile intermediate in various organic transformations. Its difluorophenyl moiety can be incorporated into diverse molecular architectures.
| Molecular weight | 157.91 |
|---|---|
| Linear formula | F2C6H3B(OH)2 |
| Application | Reactant for:• Suzuki-Miyaura cross-coupling reactions1• Preparation of selective sphingosine phosphate receptor antagonists2 |
| Melting point | 105-110 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,5-Difluorophenylboronic acid used for?
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2,5-Difluorophenylboronic acid is primarily used as a reactant in Suzuki-Miyaura cross-coupling reactions and for the preparation of selective sphingosine phosphate receptor antagonists. It also serves as a general intermediate in organic synthesis.
What is the CAS number and chemical formula for 2,5-Difluorophenylboronic acid?
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The CAS number for 2,5-Difluorophenylboronic acid is 193353-34-3. Its linear chemical formula is F2C6H3B(OH)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2,5-Difluorophenylboronic acid with a purity of 97% or higher. This product is typically supplied as a research or technical grade chemical and is not represented as USP, BP, or EP grade.
How should 2,5-Difluorophenylboronic acid be handled safely?
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Handle 2,5-Difluorophenylboronic acid with appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Avoid contact with skin and eyes, and ensure adequate ventilation.
Is 2,5-Difluorophenylboronic acid a controlled substance?
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Based on the provided data, 2,5-Difluorophenylboronic acid is not listed as a controlled substance.
How is 2,5-Difluorophenylboronic acid packed and shipped?
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2,5-Difluorophenylboronic acid is carefully packed according to international shipping regulations and is available for export globally by Tech Serve Solutions.
How can I request a quote or sample for 2,5-Difluorophenylboronic acid?
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To request a quote or a sample of 2,5-Difluorophenylboronic acid, please contact the Tech Serve Solutions sales team through our website or by phone.
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