Fmoc-Thr(tBu)-OPfp

CAS 117088-31-0C29H26F5NO5Chemical Synthesis

Fmoc-Thr(tBu)-OPfp (CAS: 117088-31-0) is a protected amino acid derivative with the empirical formula C29H26F5NO5 and a molecular weight of 563.51 g/mol. This compound serves as a valuable building block in solid-phase peptide synthesis. It is primarily utilised in chemical biology and peptide chemistry for the construction of complex peptides and peptidomimetics, ensuring controlled coupling reactions.

IUPAC: Fmoc-O-tert-butyl-L-threonine pentafluorophenyl ester

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Fmoc-Thr(tBu)-OPfp (C29H26F5NO5) — chemical structure, CAS 117088-31-0; Chemistry, fine chemical supplied by Tech Serve Solutions

Amino Acid DerivativesChemical BiologyChemical SynthesisPeptide ChemistryThreonine

01 /Applications

Solid-Phase Peptide Synthesis

Fmoc-Thr(tBu)-OPfp is a key reagent in solid-phase peptide synthesis (SPPS), facilitating the controlled addition of threonine residues to a growing peptide chain. The Fmoc and tBu protecting groups ensure regioselective coupling.

Chemical Synthesis

This compound is employed in various chemical synthesis strategies where a protected threonine moiety is required. Its structure allows for specific incorporation into complex organic molecules.

Peptide Chemistry Research

Researchers in peptide chemistry utilise Fmoc-Thr(tBu)-OPfp for the development of novel peptides with specific biological activities or structural properties. It is instrumental in creating peptide libraries for screening.

Chemical Biology

In chemical biology, this derivative aids in the synthesis of modified peptides for studying biological pathways and interactions. It is used to introduce threonine with orthogonal protection for further functionalisation.

02 /Properties

Molecular weight	563.51
Empirical formula	C29H26F5NO5
Assay	≥97.0%
Storage temperature	2-8°C

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

117088-31-0

MDL number

MFCD00077076

Beilstein registry

4627753

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Fmoc-Thr(tBu)-OPfp used for?

Fmoc-Thr(tBu)-OPfp is primarily used as a protected amino acid building block in solid-phase peptide synthesis, chemical synthesis, peptide chemistry research, and chemical biology applications.

What is the CAS number and formula for Fmoc-Thr(tBu)-OPfp?

The CAS number is 117088-31-0 and the empirical formula is C29H26F5NO5.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Fmoc-Thr(tBu)-OPfp with an assay of ≥97.0%. This product is intended for research and chemical synthesis purposes and is not represented as USP, BP, EP, or other pharmacopoeia grades.

How should Fmoc-Thr(tBu)-OPfp be handled and stored?

Handle Fmoc-Thr(tBu)-OPfp with appropriate personal protective equipment, including eyeshields and gloves. Respiratory protection such as a type N95 (US) or type P1 (EN143) respirator filter is recommended. Store at 2-8°C.