Fmoc-Thr(TBDMS)-OH
Fmoc-Thr(TBDMS)-OH (CAS 146346-82-9) is a protected threonine derivative with the molecular formula C25H33NO5Si and a molecular weight of 455.62 g/mol. This compound serves as a crucial building block in solid-phase peptide synthesis (SPPS) and other organic chemistry applications, particularly where the protection of the threonine side chain is required during complex multi-step syntheses.
- IUPAC
- Fmoc-O-(tert.-butyldimethylsilyl)-L-threonine
- Synonyms
- Fmoc-O-(tert.-butyldimethylsilyl)-L-threonine
Peptide Synthesis
Fmoc-Thr(TBDMS)-OH is utilised in solid-phase peptide synthesis to incorporate threonine residues into peptide chains. The tert-butyldimethylsilyl (TBDMS) protecting group on the side chain hydroxyl prevents unwanted reactions during coupling steps.
Organic Synthesis
As a specialised amino acid derivative, this compound is employed in various organic synthesis pathways. It allows for controlled functionalisation and elaboration of molecules where a protected threonine moiety is a necessary structural element.
Chemical Biology Research
In chemical biology, Fmoc-Thr(TBDMS)-OH can be used to synthesise peptides or peptidomimetics with specific properties for biological studies, enabling the investigation of protein structure-function relationships or the development of novel bioactive molecules.
| Molecular weight | 455.62 |
|---|---|
| Empirical formula | C25H33NO5Si |
| Assay | ≥96.0% |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-Thr(TBDMS)-OH used for?
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Fmoc-Thr(TBDMS)-OH is primarily used as a protected amino acid derivative in solid-phase peptide synthesis and other organic chemistry applications requiring a protected threonine residue.
What is the CAS number and formula for Fmoc-Thr(TBDMS)-OH?
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The CAS number is 146346-82-9, and the empirical formula is C25H33NO5Si.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-Thr(TBDMS)-OH with an assay of ≥96.0%. This product is not represented as USP, BP, EP, or pharmacopoeia grade.
How should Fmoc-Thr(TBDMS)-OH be handled and stored?
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Handle Fmoc-Thr(TBDMS)-OH with appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter may be necessary. Store the compound at 2-8°C.
Is Fmoc-Thr(TBDMS)-OH a controlled substance?
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The provided data does not indicate that Fmoc-Thr(TBDMS)-OH is a controlled substance.
How can I request a quote or sample?
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Please contact our sales team through the TSS website to request a quote or a sample of Fmoc-Thr(TBDMS)-OH.
How is this chemical packed and exported?
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Fmoc-Thr(TBDMS)-OH is carefully packed to ensure stability during transit and is available for global export by Tech Serve Solutions.
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