Fmoc-N-Me-Ile-OH
Fmoc-N-Me-Ile-OH (CAS: 138775-22-1), a derivative of isoleucine with the empirical formula C22H25NO4 and a molecular weight of 367.44 g/mol, is a key building block in peptide chemistry. This N-methylated amino acid derivative is utilised in the synthesis of peptides and peptidomimetics, offering unique structural and conformational properties. Its protected nature with the Fmoc group facilitates controlled peptide chain elongation in solid-phase and solution-phase synthesis.
- IUPAC
- Fmoc-N-methyl-L-isoleucine
- Synonyms
- Fmoc-N-methyl-L-isoleucine
Peptide Synthesis
Fmoc-N-Me-Ile-OH serves as a crucial N-methylated amino acid building block for the construction of peptides. Its incorporation can influence peptide secondary structure and receptor binding affinity.
Chemical Synthesis
As a protected amino acid derivative, it is employed in various organic synthesis pathways. The N-methylation and Fmoc protection offer specific reactivity and selectivity for complex molecule construction.
Unnatural Amino Acid Derivatives
This compound falls under unnatural amino acid derivatives, enabling the exploration and synthesis of peptides with non-proteinogenic amino acid residues for novel biological activities.
Chemical Biology Research
Its utility extends to chemical biology, where modified peptides are used to probe biological systems or develop new therapeutic agents with altered pharmacokinetic or pharmacodynamic profiles.
| Molecular weight | 367.44 |
|---|---|
| Empirical formula | C22H25NO4 |
| Assay | ≥98% (sum of enantiomers, HPLC) |
| Optical activity | [α]20/D −59±2°, c = 1% in DMF |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-N-Me-Ile-OH used for?
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Fmoc-N-Me-Ile-OH is primarily used in peptide synthesis and chemical synthesis as a protected N-methylated amino acid building block. It is valuable for creating peptides with specific structural properties and for research in chemical biology.
What is the CAS number and formula for Fmoc-N-Me-Ile-OH?
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The CAS number for Fmoc-N-Me-Ile-OH is 138775-22-1, and its empirical formula is C22H25NO4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-N-Me-Ile-OH with an assay of ≥98% (sum of enantiomers, HPLC). This product is intended for research and laboratory use. Tech Serve Solutions does not represent this product as USP, BP, EP, or other pharmacopoeia grades.
How should Fmoc-N-Me-Ile-OH be handled and stored?
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Handling requires appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or P1 (EN143) respirator filter. Store the chemical at 2-8°C.
Is Fmoc-N-Me-Ile-OH a controlled substance?
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Based on the provided data, there is no indication that Fmoc-N-Me-Ile-OH is a controlled substance.
How is Fmoc-N-Me-Ile-OH packed, shipped, and exported?
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Tech Serve Solutions securely packs and exports fine chemicals globally, adhering to all relevant regulations for safe transport.
How can I request a sample or quote for Fmoc-N-Me-Ile-OH?
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To request a sample or quote for Fmoc-N-Me-Ile-OH, please contact our sales department through the website or by phone.
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