Boc-Cys(Acm)-OH
Boc-Cys(Acm)-OH (CAS 19746-37-3) is a protected cysteine derivative with the linear formula CH3CONHCH2SCH2CH(COOH)NHCOOC(CH3)3 and a molecular weight of 292.35 g/mol. This compound serves as a valuable building block in peptide synthesis and chemical biology research. Its protected amino and carboxyl groups, along with the acetamidomethyl (Acm) protecting group on the cysteine side chain, allow for controlled incorporation into complex peptide structures and facilitate various synthetic manipulations.
- IUPAC
- Boc-S-acetamidomethyl-L-cysteine
- Synonyms
- Boc-S-acetamidomethyl-L-cysteineN-(tert-Butoxycarbonyl)-S-(acetamidomethyl)-L-cysteine
Peptide Synthesis
Boc-Cys(Acm)-OH is primarily used as a protected amino acid in solid-phase and solution-phase peptide synthesis. The Boc group protects the N-terminus, while the Acm group protects the thiol of the cysteine side chain, enabling selective deprotection and coupling strategies.
Chemical Biology
In chemical biology, this derivative is employed for introducing cysteine residues into peptides and proteins for structural or functional studies. The Acm protection can be selectively removed under specific conditions, allowing for further modification or conjugation.
Organic Synthesis
As a functionalised amino acid, Boc-Cys(Acm)-OH is a useful reagent in complex organic synthesis, particularly for constructing molecules containing modified cysteine moieties.
| Molecular weight | 292.35 |
|---|---|
| Linear formula | CH3CONHCH2SCH2CH(COOH)NHCOOC(CH3)3 |
| Assay | ≥96.0% (T) |
| Optical activity | [α]20/D −36.5±1.5°, c = 1% in H2O |
| Melting point | 111-114 °C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Boc-Cys(Acm)-OH used for?
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Boc-Cys(Acm)-OH is primarily used in peptide synthesis and chemical biology research as a protected form of cysteine.
What is the CAS number and formula for Boc-Cys(Acm)-OH?
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The CAS number is 19746-37-3 and the linear formula is CH3CONHCH2SCH2CH(COOH)NHCOOC(CH3)3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Boc-Cys(Acm)-OH with an assay of ≥96.0% (T). TSS does not represent this product as USP, BP, or EP grade.
What are the safety and handling recommendations for Boc-Cys(Acm)-OH?
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Handling Boc-Cys(Acm)-OH requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. The compound has a WGK Germany rating of 3.
Is Boc-Cys(Acm)-OH a controlled substance?
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The provided data does not indicate that Boc-Cys(Acm)-OH is a controlled substance.
How is Boc-Cys(Acm)-OH typically packed and exported?
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Tech Serve Solutions, as a global supplier and exporter, packs and ships chemicals according to international regulations for safe transport.
How can I request a quote or sample for Boc-Cys(Acm)-OH?
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Please contact our sales department directly through the website or by phone to request a quotation or a sample of Boc-Cys(Acm)-OH.
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