Fmoc-N-Me-Leu-OH
Fmoc-N-Me-Leu-OH (CAS: 103478-62-2, C22H25NO4) is a protected N-methylated amino acid derivative. It serves as a valuable building block in peptide synthesis, particularly for incorporating N-methylated residues or unnatural amino acids. This compound is crucial for creating peptides with modified structures, impacting their stability, conformation, and biological activity. Tech Serve Solutions supplies this chemical for research and development purposes in chemical biology and synthesis.
- IUPAC
- Fmoc-N-methyl-L-leucine
Peptide Synthesis
Fmoc-N-Me-Leu-OH is used in solid-phase and solution-phase peptide synthesis to introduce N-methylated leucine residues. This modification can enhance peptide stability against enzymatic degradation and influence secondary structure formation.
Chemical Biology Research
As an unnatural amino acid derivative, it enables the creation of modified peptides for probing biological systems. Researchers utilise such compounds to study protein-protein interactions or develop novel peptide-based therapeutics.
Drug Discovery and Development
Incorporating N-methylated amino acids can alter a peptide's pharmacokinetic properties, such as membrane permeability and oral bioavailability. Fmoc-N-Me-Leu-OH is a key intermediate in synthesising such peptides for drug discovery.
| Molecular weight | 367.44 |
|---|---|
| Empirical formula | C22H25NO4 |
| Assay | ≥99.0% (sum of enantiomers, HPLC) |
| Optical activity | [α]20/D −20.5±0.5°, c = 1% in DMF |
| Storage temperature | 2-8°C |
| Melting point | 113-116 °C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-N-Me-Leu-OH used for?
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Fmoc-N-Me-Leu-OH is primarily used as a building block in peptide synthesis, especially for introducing N-methylated leucine residues to modify peptide structure, stability, and biological activity in chemical biology and drug discovery research.
What is the CAS number and molecular formula of Fmoc-N-Me-Leu-OH?
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The CAS number is 103478-62-2, and the molecular formula is C22H25NO4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-N-Me-Leu-OH with an assay of ≥99.0% (sum of enantiomers, HPLC). This is a research-grade chemical and is not represented as USP, BP, EP, or pharmacopoeia grade.
How should Fmoc-N-Me-Leu-OH be handled and stored?
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Handle with appropriate personal protective equipment including eyeshields and gloves. A P1 (EN143) or N95 respirator filter is recommended. Store at 2-8°C.
Is Fmoc-N-Me-Leu-OH a controlled substance?
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The provided data does not indicate that Fmoc-N-Me-Leu-OH is a controlled substance.
How is Fmoc-N-Me-Leu-OH typically packed and exported?
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Fmoc-N-Me-Leu-OH is carefully packed for stability and safety during transit. Tech Serve Solutions is a specialist global supplier and exporter, capable of handling international shipments.
How can I request a quote or sample for Fmoc-N-Me-Leu-OH?
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Please contact our sales team through the website to request a quotation or a sample of Fmoc-N-Me-Leu-OH.
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