Fmoc-N-Me-D-Leu-OH
Fmoc-N-Me-D-Leu-OH (CAS: 103478-63-3) is an N-methylated unnatural amino acid derivative with the molecular formula C22H25NO4 and a molecular weight of 367.44 g/mol. This compound serves as a valuable building block in peptide chemistry and chemical synthesis. Its specific structure allows for incorporation into peptides to modify their properties, making it a key reagent in chemical biology research and the development of novel biomolecules.
- IUPAC
- Fmoc-N-methyl-D-leucine
- Synonyms
- Fmoc-N-methyl-D-leucine

Peptide Synthesis
Fmoc-N-Me-D-Leu-OH is utilized as a protected unnatural amino acid in solid-phase or solution-phase peptide synthesis. Its incorporation can influence peptide conformation, stability, and receptor binding properties.
Chemical Biology Research
This derivative finds application in constructing peptides with tailored functionalities for studying biological processes. It aids in the creation of peptidomimetics and probes for biochemical investigations.
Drug Discovery and Development
As a non-natural amino acid building block, Fmoc-N-Me-D-Leu-OH can be employed in the synthesis of peptide-based drug candidates, potentially offering improved pharmacokinetic profiles or enhanced therapeutic efficacy.
Organic Synthesis Intermediate
Beyond peptide chemistry, this compound can serve as an intermediate in broader organic synthesis routes where chiral, N-methylated amino acid motifs are required.
| Molecular weight | 367.44 |
|---|---|
| Empirical formula | C22H25NO4 |
| Assay | ≥97.0% |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-N-Me-D-Leu-OH used for?
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Fmoc-N-Me-D-Leu-OH is primarily used as a building block in peptide synthesis and chemical biology research for creating modified peptides and peptidomimetics.
What is the CAS number and molecular formula for Fmoc-N-Me-D-Leu-OH?
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The CAS number is 103478-63-3 and the molecular formula is C22H25NO4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-N-Me-D-Leu-OH with an assay of ≥97.0%. We do not represent this product as USP, BP, or EP grade.
How should Fmoc-N-Me-D-Leu-OH be handled and stored?
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Handle with appropriate personal protective equipment, including eyeshields and gloves. Store at 2-8°C. Refer to the safety data sheet for detailed handling and hazard information, noting a WGK rating of 3.
Is Fmoc-N-Me-D-Leu-OH exported by TSS?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including Fmoc-N-Me-D-Leu-OH.
How can I request a sample or quote for Fmoc-N-Me-D-Leu-OH?
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Please contact our sales team via the website or telephone to request a sample or a detailed quotation.
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