Fmoc-N-Me-Asp(OtBu)-OH

CAS 152548-66-8C24H27NO6Chemical Synthesis

Fmoc-N-Me-Asp(OtBu)-OH (CAS: 152548-66-8) is an Fmoc-protected N-methyl amino acid derivative with the formula C24H27NO6 and a molecular weight of 425.47 g/mol. This compound is an essential building block in peptide chemistry, particularly for solid-phase peptide synthesis. Its incorporation of an N-methyl group is known to enhance the proteolytic stability of resulting peptides, making it valuable for research in chemical biology and synthesis.

IUPAC: N-Methyl aspartic acid
Synonyms: N-Fmoc-N-methylaspartic acid beta-tert-butyl esterN-((9H-fluoren-9-ylmethoxy)carbonyl)-N-methyl-L-aspartic acid 4-tert-butyl ester

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Fmoc-N-Me-Asp(OtBu)-OH (C24H27NO6) — chemical structure, CAS 152548-66-8; Chemistry, fine chemical supplied by Tech Serve Solutions

Chemical BiologyChemical SynthesisN-Methyl Amino AcidsPeptide Chemistry

01 /Applications

Solid-Phase Peptide Synthesis

Fmoc-N-Me-Asp(OtBu)-OH is utilised as a protected amino acid building block in solid-phase peptide synthesis (SPPS). The Fmoc protecting group facilitates sequential coupling strategies.

Enhancing Peptide Stability

The N-methyl modification in this aspartic acid derivative can improve resistance to enzymatic degradation. This is crucial for developing peptides with longer half-lives in biological systems.

Chemical Biology Research

As an unnatural amino acid derivative, it enables the synthesis of modified peptides for probing biological pathways and functions. It aids in creating novel peptide structures for various research applications.

Chemical Synthesis Intermediate

This compound serves as a versatile intermediate in complex organic synthesis projects, offering a protected and modified aspartic acid moiety for incorporation into larger molecules.

02 /Properties

Molecular weight	425.47
Empirical formula	C24H27NO6
Assay	97%
Optical activity	[α]22/D -39.0°, c = 0.5% in DMF
Storage temperature	2-8°C
Application	Fmoc protected N-methyl amino acid suitable for solid phase peptide synthesis. N-methyl amino acids have been shown to improve proteolytic stability of peptides.
Melting point	135-140 °C

03 /Safety & handling

GHS hazard pictogram: Environmental hazard (GHS09) — Environmental hazard

Warning

Hazard statements

H410Very toxic to aquatic life with long-lasting effects

Precautionary statements

P273Avoid release to the environment
P501Dispose of contents and container per local regulations

Transport (UN / ADR)	UN 3077 9 / PGIII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	N
Risk statements (R)	50/53
Safety statements (S)	60-61

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

152548-66-8

MDL number

MFCD00237027

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Fmoc-N-Me-Asp(OtBu)-OH used for?

Fmoc-N-Me-Asp(OtBu)-OH is an Fmoc-protected N-methyl amino acid derivative used in solid-phase peptide synthesis to create peptides with improved proteolytic stability. It is also utilised in chemical biology and synthesis research.

What are the CAS number and formula for Fmoc-N-Me-Asp(OtBu)-OH?

The CAS number is 152548-66-8, and the empirical formula is C24H27NO6.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Fmoc-N-Me-Asp(OtBu)-OH with a minimum purity of 97%. This product is intended for research and laboratory use and is not supplied as USP, BP, EP, or pharmacopoeia grade.

What are the safety considerations when handling Fmoc-N-Me-Asp(OtBu)-OH?

Fmoc-N-Me-Asp(OtBu)-OH is classified under GHS09 with the signal word 'Warning' and carries the hazard statement H410 (Very toxic to aquatic life with long lasting effects). Handle with appropriate personal protective equipment in a well-ventilated area, and avoid release into the environment. Store at 2-8°C.

How is Fmoc-N-Me-Asp(OtBu)-OH packed, shipped, and exported?

This chemical is classified as UN 3077, Hazard Class 9, Packing Group III, for transport. It is packed and shipped according to international regulations for hazardous materials to ensure safe delivery globally.

How can I request a sample or quote for Fmoc-N-Me-Asp(OtBu)-OH?

To request a sample or a quotation, please contact our sales team via the website or direct email, providing your contact details and the quantity required.