Fmoc-N-Me-Ala-OH
Fmoc-N-Me-Ala-OH (CAS: 84000-07-7), with the molecular formula C19H19NO4 and a molecular weight of 325.36 g/mol, is a specialised N-methyl amino acid derivative. Utilised in chemical synthesis and peptide chemistry, this compound is valuable for introducing N-methylated alanine into peptide sequences. Its application extends to chemical biology research, enabling the study of modified peptides with altered conformational or biological properties. Tech Serve Solutions offers this high-purity reagent for demanding research and development.
- IUPAC
- Fmoc-N-methyl-L-alanine
Peptide Synthesis
Fmoc-N-Me-Ala-OH serves as a crucial building block in solid-phase and solution-phase peptide synthesis. It enables the incorporation of N-methylated alanine, which can significantly alter peptide structure, stability, and receptor binding affinity.
Chemical Biology Research
This unnatural amino acid derivative is employed in the design and synthesis of peptides for studying protein-ligand interactions, enzyme mechanisms, and biological pathways. Its use allows for probing the effects of N-methylation on peptide conformation and function.
Drug Discovery and Development
Incorporating N-methylated amino acids like Fmoc-N-Me-Ala-OH into peptidomimetics can enhance metabolic stability and oral bioavailability, making it a valuable tool in the search for novel therapeutic agents.
Organic Synthesis
As a chiral building block, Fmoc-N-Me-Ala-OH can be used in various complex organic synthesis pathways where the specific stereochemistry and N-methylated alanine moiety are required.
| Molecular weight | 325.36 |
|---|---|
| Empirical formula | C19H19NO4 |
| Assay | ≥97.0% (sum of enantiomers, HPLC) |
| Optical activity | [α]20/D −18.5±1°, c = 1% in DMF |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-N-Me-Ala-OH used for?
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Fmoc-N-Me-Ala-OH is primarily used in peptide synthesis and chemical biology research as a building block for creating peptides containing N-methylated alanine. This modification can influence peptide structure, stability, and biological activity, making it useful in drug discovery and for studying biological systems.
What are the CAS number and chemical formula for Fmoc-N-Me-Ala-OH?
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The CAS number for Fmoc-N-Me-Ala-OH is 84000-07-7, and its empirical formula (Hill notation) is C19H19NO4.
What grade and purity does Tech Serve Solutions supply for Fmoc-N-Me-Ala-OH?
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Tech Serve Solutions supplies Fmoc-N-Me-Ala-OH with an assay of ≥97.0% (sum of enantiomers, HPLC). This product is intended for research and development purposes and is not supplied as USP, BP, EP, or pharmaceutical grade.
What are the safety and handling recommendations for Fmoc-N-Me-Ala-OH?
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When handling Fmoc-N-Me-Ala-OH, appropriate personal protective equipment including eyeshields and gloves should be worn. A type N95 (US) or type P1 (EN143) respirator filter is recommended. This compound is classified under WGK Germany 3, indicating a high hazard to water.
How is Fmoc-N-Me-Ala-OH typically stored and shipped?
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Fmoc-N-Me-Ala-OH requires storage at a temperature of 2-8°C. Tech Serve Solutions ensures that all chemicals are packed and exported in compliance with international shipping regulations for chemical reagents.
How can I request a sample or quote for Fmoc-N-Me-Ala-OH?
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To request a sample or a quotation for Fmoc-N-Me-Ala-OH, please visit the Tech Serve Solutions website or contact our sales department directly through the provided contact information.
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