Fmoc-Hyp(tBu)-OH
Fmoc-Hyp(tBu)-OH (CAS: 122996-47-8) is a protected amino acid derivative with the molecular formula C24H27NO5 and a molecular weight of 409.47 g/mol. This compound features a tert-butyl protecting group on the hydroxyl of hydroxyproline and an Fmoc group on the amine, making it valuable in solid-phase peptide synthesis. It is primarily employed in the creation of peptides and peptidomimetics within chemical biology and synthetic chemistry research.
- IUPAC
- Fmoc-O-tert-butyl-L-hydroxyproline
- Synonyms
- Fmoc-O-tert-butyl-L-hydroxyproline
Peptide Synthesis
Fmoc-Hyp(tBu)-OH is a key building block in solid-phase peptide synthesis (SPPS) using the Fmoc/tBu strategy. The tert-butyl group protects the hydroxyl functionality of hydroxyproline during coupling, while the Fmoc group allows for facile deprotection and chain elongation.
Chemical Biology Research
This unnatural amino acid derivative facilitates the synthesis of peptides with modified structures for studying biological processes. Its incorporation can lead to peptides with altered stability, conformation, or receptor binding properties.
Drug Discovery and Development
Used in the development of novel therapeutic peptides and peptidomimetics, Fmoc-Hyp(tBu)-OH aids in the creation of compounds with potential pharmaceutical applications by introducing structural diversity.
| Molecular weight | 409.47 |
|---|---|
| Empirical formula | C24H27NO5 |
| Assay | ≥98.0% (HPLC) |
| Optical activity | [α]20/D −25±2.5°, c = 1% in methanol |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-Hyp(tBu)-OH used for?
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Fmoc-Hyp(tBu)-OH is primarily used as a protected amino acid building block in solid-phase peptide synthesis, particularly within chemical biology and pharmaceutical research for creating modified peptides.
What are the CAS number and formula for Fmoc-Hyp(tBu)-OH?
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The CAS number for Fmoc-Hyp(tBu)-OH is 122996-47-8, and its molecular formula is C24H27NO5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-Hyp(tBu)-OH with an assay of ≥98.0% by HPLC. This product is intended for research and laboratory use and is not represented as USP, BP, or EP grade.
How should Fmoc-Hyp(tBu)-OH be handled and stored?
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Handle Fmoc-Hyp(tBu)-OH with appropriate personal protective equipment, including eyeshields and gloves. A type N95 respirator filter is recommended. Store the compound at 2-8°C.
How is this chemical packed, shipped, and exported?
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Fmoc-Hyp(tBu)-OH is carefully packed to ensure stability during transit and is exported globally by Tech Serve Solutions, adhering to all relevant shipping regulations.
How can I request a sample or a quote for Fmoc-Hyp(tBu)-OH?
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To request a sample or a quotation for Fmoc-Hyp(tBu)-OH, please contact our sales department through the TSS website or by direct inquiry.
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