Fmoc-Hyp-OH
Fmoc-Hyp-OH (CAS 88050-17-3), with the molecular formula C20H19NO5 and a molecular weight of 353.37 g/mol, is a key unnatural amino acid derivative. It is widely employed in peptide chemistry and chemical synthesis. This compound is particularly valuable for introducing modified proline residues into peptides, facilitating the study of peptide structure and function in chemical biology research. Its specific optical activity is also a critical parameter for its application in stereoselective synthesis.
- IUPAC
- Fmoc-L-4-hydroxyproline
- Synonyms
- Fmoc-L-4-hydroxyproline
Peptide Synthesis
Fmoc-Hyp-OH serves as a crucial building block in solid-phase and solution-phase peptide synthesis. Its Fmoc protecting group allows for orthogonal deprotection strategies, enabling the controlled assembly of complex peptide sequences incorporating hydroxyproline residues.
Chemical Biology Research
This unnatural amino acid derivative is instrumental in creating peptides with altered structural or functional properties. Researchers utilise it to probe peptide-protein interactions, enzyme mechanisms, and the biological roles of modified peptides.
Drug Discovery
Incorporating Fmoc-Hyp-OH into peptide-based drug candidates can influence their stability, bioavailability, and receptor binding affinity. It provides a versatile tool for medicinal chemists in the design of novel therapeutics.
Material Science
Modified peptides containing hydroxyproline can self-assemble into novel biomaterials. Fmoc-Hyp-OH is used to synthesise peptides with specific properties for applications in tissue engineering and advanced materials.
| Molecular weight | 353.37 |
|---|---|
| Empirical formula | C20H19NO5 |
| Assay | ≥98.0% (sum of enantiomers, HPLC) |
| Optical activity | [α]20/D −60±2°, c = 1% in methanol |
| Storage temperature | 2-8°C |
| Melting point | 189-193 °C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-Hyp-OH used for?
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Fmoc-Hyp-OH is primarily used in peptide synthesis, chemical biology research, and drug discovery as a protected unnatural amino acid derivative for incorporating modified proline residues into peptide chains.
What is the CAS number and molecular formula of Fmoc-Hyp-OH?
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The CAS number for Fmoc-Hyp-OH is 88050-17-3, and its molecular formula is C20H19NO5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-Hyp-OH with a purity of ≥98.0% (sum of enantiomers, HPLC). TSS does not represent this product as USP, BP, or EP grade.
How should Fmoc-Hyp-OH be handled and stored?
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Fmoc-Hyp-OH should be handled with appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or P1 (EN143) respirator filter may be necessary. It should be stored at 2-8°C.
Is Fmoc-Hyp-OH a controlled substance?
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Based on the provided data, Fmoc-Hyp-OH is not listed as a controlled substance.
How can I request a quote or sample for Fmoc-Hyp-OH?
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To request a quote or sample of Fmoc-Hyp-OH, please contact our sales team through the website or by phone. We export globally.
What is the melting point of Fmoc-Hyp-OH?
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The melting point of Fmoc-Hyp-OH is reported to be between 189-193°C.
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