Fmoc-Ile-OPfp
Fmoc-Ile-OPfp (CAS 86060-89-1), with the molecular formula C27H22F5NO4 and a molecular weight of 519.46 g/mol, is a protected amino acid derivative. It is primarily utilised in solid-phase peptide synthesis (SPPS) and solution-phase peptide synthesis. This compound serves as a crucial building block for the incorporation of the isoleucine residue into peptide chains, facilitating the creation of complex peptides for research and development in chemical biology and related fields.
- IUPAC
- Fmoc-L-isoleucine pentafluorophenyl ester
- Synonyms
- Fmoc-L-isoleucine pentafluorophenyl ester
Solid-Phase Peptide Synthesis (SPPS)
Fmoc-Ile-OPfp is widely employed as an N-terminal protected isoleucine derivative in SPPS. The Fmoc group allows for orthogonal deprotection strategies, enabling the sequential addition of amino acids to a solid support to construct peptide sequences.
Solution-Phase Peptide Synthesis
This reagent can also be utilised in solution-phase synthesis, where it facilitates the coupling of isoleucine into peptides in homogeneous reaction conditions. Its reactive pentafluorophenyl ester moiety ensures efficient amide bond formation.
Peptide Chemistry Research
As a key intermediate, Fmoc-Ile-OPfp is indispensable for researchers investigating novel peptide structures, peptidomimetics, and peptide-based therapeutics. It supports the precise assembly of isoleucine-containing peptides for biological studies.
Chemical Biology and Medicinal Chemistry
The compound aids in the synthesis of peptides designed to probe biological pathways or act as potential drug candidates. Its application spans the development of biologically active molecules and research tools in these disciplines.
| Molecular weight | 519.46 |
|---|---|
| Empirical formula | C27H22F5NO4 |
| Assay | ≥98.0% (TLC) |
| Storage temperature | 2-8°C |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-Ile-OPfp used for?
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Fmoc-Ile-OPfp is principally used as a protected amino acid derivative in solid-phase and solution-phase peptide synthesis for the incorporation of isoleucine into peptide sequences during chemical and biochemical research.
What is the CAS number and formula for Fmoc-Ile-OPfp?
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The CAS number is 86060-89-1, and the empirical formula (Hill notation) is C27H22F5NO4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-Ile-OPfp with an assay of ≥98.0% (TLC). We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should Fmoc-Ile-OPfp be handled and stored?
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Fmoc-Ile-OPfp is a Warning substance (H302, H315, H319, H335). Handle with appropriate personal protective equipment including eyeshields and gloves, and wear a dust mask type N95. Store at 2-8°C to maintain its integrity.
How is Fmoc-Ile-OPfp packed, shipped, and exported?
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Fmoc-Ile-OPfp is carefully packed to ensure stability during transit and is exported globally by Tech Serve Solutions, a specialist supplier.
How can I request a sample or quote for Fmoc-Ile-OPfp?
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Please contact Tech Serve Solutions directly through our website or sales department to request a sample or obtain a quotation for Fmoc-Ile-OPfp.
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