Fmoc-Leu-OH
Fmoc-Leu-OH (CAS 35661-60-0), chemically known as N-(9-Fluorenylmethoxycarbonyl)-L-leucine, is a protected amino acid derivative with the molecular formula C21H23NO4. This white to off-white solid is primarily employed in solid-phase peptide synthesis (SPPS) as a key building block. Its Fmoc protecting group facilitates controlled peptide chain elongation. The compound is essential for researchers in medicinal chemistry, biochemistry, and drug discovery programmes requiring custom peptide synthesis.
- IUPAC
- N-(9-Fluorenylmethoxycarbonyl)-L-leucine,Fmoc-L-leucine
- Synonyms
- N-(9-Fluorenylmethoxycarbonyl)-L-leucineFmoc-L-leucine
Solid-Phase Peptide Synthesis (SPPS)
Fmoc-Leu-OH is widely utilized in SPPS to incorporate L-leucine into peptide chains. The base-labile Fmoc group allows for selective deprotection under mild conditions, enabling sequential amino acid addition and the construction of complex peptide sequences.
Custom Peptide Synthesis
As a crucial reagent for peptide chemistry, Fmoc-Leu-OH supports the synthesis of custom peptides for research in drug development, proteomics, and biological studies. Its high purity ensures reliable incorporation into target peptide structures.
Biochemical Research
Researchers in biochemistry and chemical biology use Fmoc-Leu-OH to create peptides with specific functionalities or to study peptide-protein interactions. It serves as a fundamental component in the synthesis of peptides for various biological assays.
| Molecular weight | 353.41 |
|---|---|
| Empirical formula | C21H23NO4 |
| Assay | ≥97.0% |
| Optical activity | [α]20/D −25±2°, c = 1% in DMF |
| Storage temperature | 2-8°C |
| Melting point | 152-156 °C(lit.)152-156 °C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-Leu-OH primarily used for?
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Fmoc-Leu-OH is primarily used as a protected amino acid in solid-phase peptide synthesis (SPPS) for the controlled incorporation of L-leucine into peptide chains.
What is the CAS number and chemical formula for Fmoc-Leu-OH?
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The CAS number for Fmoc-Leu-OH is 35661-60-0, and its chemical formula is C21H23NO4.
What grade and purity does Tech Serve Solutions supply for Fmoc-Leu-OH?
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Tech Serve Solutions supplies Fmoc-Leu-OH with an assay of ≥97.0%. We do not represent this product as USP, BP, or EP grade unless explicitly stated.
How should Fmoc-Leu-OH be handled and stored?
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Fmoc-Leu-OH should be handled with appropriate personal protective equipment, including eyeshields and gloves. It requires storage at 2-8°C to maintain its stability and efficacy.
Is Fmoc-Leu-OH a controlled substance?
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The provided data does not indicate that Fmoc-Leu-OH is a controlled substance.
How can I request a quote or sample for Fmoc-Leu-OH?
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To request a quote or sample, please contact the Tech Serve Solutions sales team through our website or by phone, specifying the product name and CAS number (35661-60-0).
How is Fmoc-Leu-OH packed and exported?
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Fmoc-Leu-OH is carefully packed to ensure stability during transit and is available for export globally by Tech Serve Solutions, adhering to all relevant shipping regulations.
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