Fmoc-Leu-OPfp
Fmoc-Leu-OPfp (CAS 86060-88-0) is a crucial building block in peptide synthesis, featuring the Fmoc protecting group and a pentafluorophenyl ester for efficient coupling. With the chemical formula C27H22F5NO4 and a molecular weight of 519.46 g/mol, this Leucine derivative is primarily employed in solid-phase and solution-phase peptide chemistry for the construction of complex peptide chains. Its reactive ester facilitates controlled amino acid incorporation during synthesis.
- IUPAC
- Fmoc-L-leucine pentafluorophenyl ester
- Synonyms
- Fmoc-L-leucine pentafluorophenyl ester
Peptide Synthesis
Fmoc-Leu-OPfp is widely utilized in solid-phase and solution-phase peptide synthesis. The Fmoc group allows for orthogonal protection strategies, while the pentafluorophenyl ester provides an activated leaving group for efficient amide bond formation with amino groups.
Chemical Biology Research
This compound serves as a valuable reagent in chemical biology for incorporating modified leucine residues into peptides. This enables the study of peptide structure-function relationships and the development of peptide-based therapeutics or probes.
Organic Synthesis
Beyond peptide chemistry, Fmoc-Leu-OPfp can be employed in general organic synthesis where a protected leucine moiety with an activated ester is required for specific coupling reactions or the creation of complex organic molecules.
| Molecular weight | 519.46 |
|---|---|
| Empirical formula | C27H22F5NO4 |
| Assay | ≥98.0% |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-Leu-OPfp used for?
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Fmoc-Leu-OPfp is used as a key reagent in peptide synthesis, enabling the introduction of Fmoc-protected leucine into peptide chains via its activated pentafluorophenyl ester. It is also used in chemical biology and organic synthesis.
What are the CAS number and formula for Fmoc-Leu-OPfp?
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The CAS number for Fmoc-Leu-OPfp is 86060-88-0, and its empirical formula is C27H22F5NO4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-Leu-OPfp with a purity of ≥98.0%. This is a research-grade chemical and is not represented as USP, BP, or EP grade.
How should Fmoc-Leu-OPfp be handled and stored?
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Handle Fmoc-Leu-OPfp with appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Store the chemical at 2-8°C.
Is Fmoc-Leu-OPfp a controlled substance?
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The provided data does not indicate that Fmoc-Leu-OPfp is a controlled substance.
How is Fmoc-Leu-OPfp packed and shipped?
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Fmoc-Leu-OPfp is carefully packed according to industry standards to ensure safe transit and is available for global export by Tech Serve Solutions.
How can I request a sample or quote for Fmoc-Leu-OPfp?
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To request a sample or obtain a quote for Fmoc-Leu-OPfp, please contact our sales team through the website or by phone.
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