Fmoc-Lys(Boc)-OH

CAS 71989-26-9C26H32N2O6Chemical Synthesis

Nα-Fmoc-Nε-Boc-L-lysine (CAS: 71989-26-9), a critical derivative of the amino acid lysine, is a fundamental building block in peptide synthesis. With the molecular formula C26H32N2O6 and a molecular weight of 468.54 g/mol, this compound features orthogonal protection on its amino groups. It is essential for solid-phase peptide synthesis (SPPS) and is widely employed in research and development across chemical biology and synthesis laboratories.

IUPAC: Nα-Fmoc-Nε-Boc-L-lysine
Synonyms: Nα-Fmoc-Nε-Boc-L-lysine

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Fmoc-Lys(Boc)-OH (C26H32N2O6) — chemical structure, CAS 71989-26-9; Chemistry, fine chemical supplied by Tech Serve Solutions

Amino Acid DerivativesChemical BiologyChemical SynthesisLysinePeptide Chemistry

01 /Applications

Peptide Synthesis

Serves as a protected lysine residue in the construction of peptides and proteins using Fmoc-based solid-phase peptide synthesis (SPPS). Its orthogonal protecting groups (Fmoc and Boc) allow for selective deprotection strategies during chain elongation.

Chemical Biology Research

Utilised in creating modified peptides for studying protein function, developing drug conjugates, and in biochemical assays. The controlled introduction of lysine into peptide sequences enables specific structural or functional modifications.

Drug Discovery and Development

Incorporated into peptide-based therapeutics and drug candidates. The protected lysine side chain can be further functionalised for targeted drug delivery or to enhance pharmacokinetic properties.

Organic Synthesis

Acts as a chiral building block in complex organic synthesis pathways, leveraging the protected amino and carboxyl functionalities for various chemical transformations.

02 /Properties

Molecular weight	468.54
Empirical formula	C26H32N2O6
Assay	≥98.0% (HPLC)
Optical activity	[α]20/D −12±1°, c = 1% in DMF
Storage temperature	2-8°C

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

71989-26-9

MDL number

MFCD00037138

Beilstein registry

4217767

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Fmoc-Lys(Boc)-OH used for?

Fmoc-Lys(Boc)-OH is primarily used as a protected amino acid in Fmoc-based solid-phase peptide synthesis (SPPS) for creating peptides and in chemical biology research and drug discovery.

What are the CAS number and formula for Fmoc-Lys(Boc)-OH?

The CAS number for Fmoc-Lys(Boc)-OH is 71989-26-9, and its empirical formula is C26H32N2O6.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Fmoc-Lys(Boc)-OH with an assay of ≥98.0% (HPLC). TSS does not represent this product as USP, BP, EP, or pharmacopoeia grade.

What are the safety and handling recommendations for Fmoc-Lys(Boc)-OH?

Handling Fmoc-Lys(Boc)-OH requires appropriate personal protective equipment, including eyeshields, gloves, and a P1 (EN143) or N95 respirator filter. It is classified under WGK Germany 3, indicating a high hazard to water.

How is Fmoc-Lys(Boc)-OH typically stored and shipped?

This compound should be stored at 2-8°C. TSS exports fine chemicals globally, ensuring appropriate packaging and documentation for safe international transport.