Fmoc-His(Trt)-OPfp
Nα-Fmoc-N(im)-trityl-L-histidine pentafluorophenyl ester (CAS: 109434-24-4) is a protected amino acid derivative with the empirical formula C46H32F5N3O4. Its molecular weight is 785.76 g/mol. This compound is primarily utilised in solid-phase peptide synthesis and other organic chemistry applications requiring the incorporation of a histidine residue with specific protecting groups.
- IUPAC
- Nα-Fmoc-N(im)-trityl-L-histidine pentafluorophenyl ester
Peptide Synthesis
Serves as a crucial building block in solid-phase peptide synthesis (SPPS) and solution-phase methods. The Fmoc and Trt protecting groups facilitate controlled coupling and deprotection strategies for constructing complex peptide sequences.
Chemical Biology Research
Used in the synthesis of modified peptides for probing biological pathways, protein interactions, and enzyme mechanisms. Its specific protecting groups allow for selective modifications and functionalization.
Organic Synthesis
Acts as a versatile intermediate in the synthesis of various organic molecules. The pentafluorophenyl ester moiety can be activated for nucleophilic attack, enabling diverse synthetic transformations.
| Molecular weight | 785.76 |
|---|---|
| Empirical formula | C46H32F5N3O4 |
| Assay | ≥75% (TLC) |
| Storage temperature | 2-8°C |
| Impurities tested | ~1 mol/mol cyclohexane~1 mol/mol pentalfuorophenol |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-His(Trt)-OPfp used for?
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Fmoc-His(Trt)-OPfp is used as a building block in solid-phase peptide synthesis and other organic chemistry applications requiring the incorporation of a histidine residue with Fmoc and Trt protecting groups.
What is the CAS number and formula for Fmoc-His(Trt)-OPfp?
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The CAS number is 109434-24-4 and the empirical formula is C46H32F5N3O4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product with an assay of ≥75% (TLC). We do not represent this product as USP, BP, EP, or pharmacopoeia grade.
What are the safety and handling precautions for Fmoc-His(Trt)-OPfp?
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Handle with appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or P1 (EN143) respirator filter. The compound is classified under WGK Germany 3.
How is Fmoc-His(Trt)-OPfp shipped or exported?
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Fmoc-His(Trt)-OPfp is typically stored at 2-8°C. Shipping and export comply with all relevant regulations for chemical compounds.
How can I request a sample or quote for Fmoc-His(Trt)-OPfp?
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Please contact our sales team through the website or by phone to request a sample or a detailed quotation.
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