Fmoc-His(Trt)-OH
Fmoc-His(Trt)-OH (CAS: 109425-51-6), a derivative of L-histidine with the molecular formula C40H33N3O4 and a molecular weight of 619.71 g/mol, is a critical building block in peptide synthesis. The trityl (Trt) group protects the imidazole nitrogen, and the Fmoc group protects the alpha-amino group, facilitating controlled chain elongation in solid-phase and solution-phase peptide synthesis. Its high purity ensures reliable results in chemical biology and synthesis applications.
- IUPAC
- Nα-Fmoc-N(im)-trityl-L-histidine
- Synonyms
- Nα-Fmoc-N(im)-trityl-L-histidine
Peptide Synthesis
Fmoc-His(Trt)-OH is extensively used as a protected histidine building block in solid-phase peptide synthesis (SPPS) and solution-phase methods. It enables the incorporation of histidine residues into peptides while preventing side reactions at the imidazole nitrogen.
Chemical Biology Research
This compound serves as a valuable reagent in chemical biology for the synthesis of modified peptides, peptidomimetics, and other biomolecules. It aids in studying protein structure-function relationships and developing novel therapeutic agents.
Organic Synthesis
As a protected amino acid derivative, Fmoc-His(Trt)-OH is applicable in various organic synthesis strategies requiring the precise introduction of a histidine moiety into complex molecular architectures.
| Molecular weight | 619.71 |
|---|---|
| Empirical formula | C40H33N3O4 |
| Assay | ≥98.0% (sum of enantiomers, HPLC) |
| Storage temperature | 2-8°C |
| Melting point | 150-155 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-His(Trt)-OH used for?
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Fmoc-His(Trt)-OH is primarily used as a protected building block in peptide synthesis, particularly in solid-phase and solution-phase methods. It is also utilized in chemical biology and general organic synthesis for incorporating histidine into peptides and other complex molecules.
What are the CAS number and formula for Fmoc-His(Trt)-OH?
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The CAS number for Fmoc-His(Trt)-OH is 109425-51-6, and its empirical formula is C40H33N3O4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-His(Trt)-OH with a purity of ≥98.0% (sum of enantiomers, HPLC). This product is intended for research and laboratory use. TSS does not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should Fmoc-His(Trt)-OH be handled and stored?
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Handle Fmoc-His(Trt)-OH with appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or P1 (EN143) respirator filter. It should be stored at 2-8°C. The compound is classified under WGK Germany 3, indicating it is hazardous to water.
How can I request a quote or sample for Fmoc-His(Trt)-OH?
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To request a quote or sample of Fmoc-His(Trt)-OH, please contact our sales team through the website or by phone. Provide the product name and CAS number (109425-51-6) for efficient processing.
Is Fmoc-His(Trt)-OH a controlled substance?
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The provided data does not indicate that Fmoc-His(Trt)-OH is a controlled substance.
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