Fmoc-His(Tos)-OH
Fmoc-His(Tos)-OH (CAS: 112380-10-6) is a protected amino acid derivative with the molecular formula C28H25N3O6S. It features the Fmoc protecting group on the alpha-amino function and a tosyl group on the imidazole nitrogen of histidine. This compound is primarily utilised in solid-phase peptide synthesis (SPPS) and solution-phase synthesis of peptides containing histidine residues. Its specific protection strategy allows for controlled deprotection and coupling reactions in complex peptide assembly.
- IUPAC
- Nα-Fmoc-N(im)-tosyl-L-histidine
Peptide Synthesis
Fmoc-His(Tos)-OH is a key building block in solid-phase peptide synthesis (SPPS) for incorporating histidine residues into peptide chains. The orthogonal protecting groups (Fmoc and Tosyl) enable selective deprotection strategies.
Biochemical Research
This derivative is valuable in biochemical research for synthesising peptides with specific structural or functional properties. It aids in studying peptide-protein interactions and developing peptide-based therapeutics.
Organic Synthesis
Beyond peptide synthesis, Fmoc-His(Tos)-OH can serve as a chiral synthon in complex organic synthesis pathways requiring a protected histidine moiety.
| Molecular weight | 531.58 |
|---|---|
| Empirical formula | C28H25N3O6S |
| Assay | ≥98.0% (calc. based on dry substance, C/N) |
| Grade | purum |
| Optical activity | [α]20/D −7±1°, c = 1% in DMF |
| Storage temperature | 2-8°C |
| Melting point | 170-174 °C (dec.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-His(Tos)-OH used for?
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Fmoc-His(Tos)-OH is primarily used as a protected building block in solid-phase and solution-phase peptide synthesis for the incorporation of histidine residues.
What is the CAS number and formula for Fmoc-His(Tos)-OH?
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The CAS number for Fmoc-His(Tos)-OH is 112380-10-6, and its molecular formula is C28H25N3O6S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-His(Tos)-OH with a purity of ≥98.0% (calc. based on dry substance, C/N) and a 'purum' grade. We do not represent this product as meeting USP, BP, or EP pharmacopoeial standards.
How should Fmoc-His(Tos)-OH be handled and stored?
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Handle Fmoc-His(Tos)-OH with appropriate personal protective equipment, including eyeshields and gloves. A respirator filter of type N95 (US) or P1 (EN143) is recommended. Store at 2-8°C to maintain stability.
Is Fmoc-His(Tos)-OH a controlled substance?
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The provided data does not indicate that Fmoc-His(Tos)-OH is a controlled substance.
How can I request a quote or sample of Fmoc-His(Tos)-OH?
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To request a quote or a sample of Fmoc-His(Tos)-OH, please contact the Tech Serve Solutions sales team through our website or via direct inquiry, providing your contact details and the product CAS number.
How is Fmoc-His(Tos)-OH packaged and exported?
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Fmoc-His(Tos)-OH is carefully packaged to ensure stability and safety during transit. Tech Serve Solutions is experienced in exporting fine chemicals globally, adhering to all relevant shipping regulations.
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