Fmoc-His(Bzl)-OH
Fmoc-His(Bzl)-OH (CAS: 84030-19-3) is a protected derivative of the amino acid L-histidine, with the empirical formula C28H25N3O4 and a molecular weight of 467.52 g/mol. This compound features an Fmoc protecting group on the alpha-amino group and a benzyl protecting group on the imidazole ring. It is primarily utilised in solid-phase peptide synthesis and other research applications within chemical biology and organic synthesis.
- IUPAC
- Nα-Fmoc-N(im)-benzyl-L-histidine
- Synonyms
- Nα-Fmoc-N(im)-benzyl-L-histidine
Peptide Synthesis
Fmoc-His(Bzl)-OH is a key building block in solid-phase peptide synthesis (SPPS) for incorporating histidine residues into peptide chains. The Fmoc group allows for base-labile deprotection, while the benzyl group protects the imidazole side chain during synthesis.
Chemical Biology Research
This protected amino acid is employed in research settings to construct peptides with specific functionalities or to study biological processes involving histidine-containing peptides.
Organic Synthesis
Beyond peptide synthesis, Fmoc-His(Bzl)-OH serves as a versatile intermediate in complex organic synthesis pathways requiring the controlled introduction of a histidine moiety.
| Molecular weight | 467.52 |
|---|---|
| Empirical formula | C28H25N3O4 |
| Assay | ≥98.0% (HPLC) |
| Optical activity | [α]20/D +118±3°, c = 1% in chloroform |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-His(Bzl)-OH used for?
+
Fmoc-His(Bzl)-OH is primarily used as a protected amino acid in solid-phase peptide synthesis and for research in chemical biology and organic synthesis.
What are the CAS number and formula for Fmoc-His(Bzl)-OH?
+
The CAS number is 84030-19-3 and the empirical formula is C28H25N3O4.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies Fmoc-His(Bzl)-OH with an assay of ≥98.0% (HPLC). We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade. For specific purity requirements, please contact our sales team.
What are the safety considerations for handling Fmoc-His(Bzl)-OH?
+
Handle Fmoc-His(Bzl)-OH with appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. It carries a WGK rating of 3 in Germany.
How is Fmoc-His(Bzl)-OH packed and shipped?
+
Fmoc-His(Bzl)-OH is stored at 2-8°C. TSS ensures that all products are carefully packed and exported in compliance with international regulations.
How can I request a quote or sample for Fmoc-His(Bzl)-OH?
+
Please contact the Tech Serve Solutions sales team via our website or direct email to request a quote or a sample.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis