Fmoc-Cys(Trt)-OH

CAS 103213-32-7C37H31NO4SChemical Synthesis

N-(9-Fluorenylmethoxycarbonyl)-S-trityl-L-cysteine (CAS: 103213-32-7), a protected amino acid derivative with the formula C37H31NO4S and a molecular weight of 585.71 g/mol, is crucial in peptide synthesis. Its trityl group offers robust protection for the cysteine thiol, while the Fmoc group facilitates orthogonal deprotection strategies. This compound is widely employed in solid-phase peptide synthesis (SPPS) and for constructing complex peptide sequences where cysteine modification is required.

IUPAC: N-(9-Fluorenylmethoxycarbonyl)-S-trityl-L-cysteine,Nα-Fmoc-S-trityl-L-cysteine
Synonyms: N-(9-Fluorenylmethoxycarbonyl)-S-trityl-L-cysteineNα-Fmoc-S-trityl-L-cysteine

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Fmoc-Cys(Trt)-OH (C37H31NO4S) — chemical structure, CAS 103213-32-7; Chemistry, fine chemical supplied by Tech Serve Solutions

Amino Acid DerivativesChemical BiologyChemical SynthesisCysteine/CystinePeptide Chemistry

01 /Applications

Peptide Synthesis

Used as a building block in solid-phase and solution-phase peptide synthesis. The Fmoc and Trityl protecting groups allow for selective deprotection and coupling steps, enabling the construction of complex peptide chains.

Chemical Biology

Enables the introduction of cysteine residues into peptides for bioconjugation or to study protein structure-function relationships. Its protected form allows for controlled incorporation into biomolecules.

Chemical Synthesis

Serves as a versatile intermediate in organic synthesis, particularly for creating molecules containing modified cysteine residues. The protecting groups can be removed under specific conditions for further functionalization.

02 /Properties

Molecular weight	585.71
Empirical formula	C37H31NO4S
Assay	≥95.0% (sum of enantiomers, HPLC)
Optical activity	[α]20/D +16.0±2°, c = 1% in THF
Storage temperature	2-8°C
Melting point	170-173 °C(lit.)

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

103213-32-7

MDL number

MFCD00038538

Beilstein registry

4221286

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Fmoc-Cys(Trt)-OH primarily used for?

Fmoc-Cys(Trt)-OH is primarily used as a protected amino acid building block in solid-phase peptide synthesis (SPPS) and for the synthesis of complex peptides where selective protection of the cysteine thiol group is necessary.

What is the CAS number and chemical formula for Fmoc-Cys(Trt)-OH?

The CAS number is 103213-32-7, and the empirical formula is C37H31NO4S.

What grade and purity does Tech Serve Solutions supply for Fmoc-Cys(Trt)-OH?

Tech Serve Solutions supplies Fmoc-Cys(Trt)-OH with an assay of ≥95.0% (sum of enantiomers, HPLC). This product is supplied for research and development purposes and is not intended for use as USP, BP, EP, or pharmacopoeia grade.

What are the safety and handling precautions for Fmoc-Cys(Trt)-OH?

Handling Fmoc-Cys(Trt)-OH requires appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter. It has a WGK Germany rating of 3, indicating a high hazard.

How is Fmoc-Cys(Trt)-OH packed, shipped, and exported?

Fmoc-Cys(Trt)-OH is typically stored at 2-8°C. Tech Serve Solutions professionally packs, ships, and exports fine chemicals globally, adhering to all relevant regulations for safe transport.