Fmoc-D-1-Nal-OH
Fmoc-D-1-Nal-OH (CAS 138774-93-3), with the empirical formula C28H23NO4 and a molecular weight of 437.49 g/mol, is a protected unnatural amino acid derivative. It is primarily utilised in solid-phase peptide synthesis (SPPS) and for the construction of peptides containing non-proteinogenic amino acids. This compound is crucial for research in medicinal chemistry and drug discovery, enabling the development of novel peptide-based therapeutics.
- IUPAC
- Fmoc-3-(1-naphthyl)-D-alanine
- Synonyms
- Fmoc-3-(1-naphthyl)-D-alanine
Peptide Synthesis
Fmoc-D-1-Nal-OH serves as a key building block in Fmoc solid-phase peptide synthesis (SPPS). Its inclusion allows for the incorporation of a non-proteinogenic D-naphthylalanine residue, offering unique structural and functional properties to synthetic peptides.
Medicinal Chemistry
This unnatural amino acid derivative is employed in medicinal chemistry for the design and synthesis of modified peptides. These modifications can enhance stability, alter receptor binding affinity, or introduce specific pharmacological activities.
Drug Discovery
Researchers utilise Fmoc-D-1-Nal-OH in drug discovery programs to explore novel peptide scaffolds. The introduction of unnatural amino acids like this can lead to the development of peptide analogues with improved pharmacokinetic profiles or novel therapeutic applications.
| Molecular weight | 437.49 |
|---|---|
| Empirical formula | C28H23NO4 |
| Assay | ≥96.0% (HPLC) |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-D-1-Nal-OH used for?
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Fmoc-D-1-Nal-OH is used as a protected building block in solid-phase peptide synthesis, particularly for incorporating unnatural D-naphthylalanine residues into peptides for research in medicinal chemistry and drug discovery.
What is the CAS number and formula for Fmoc-D-1-Nal-OH?
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The CAS number for Fmoc-D-1-Nal-OH is 138774-93-3, and its empirical formula is C28H23NO4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-D-1-Nal-OH with a purity of ≥96.0% (HPLC). TSS does not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety considerations for handling Fmoc-D-1-Nal-OH?
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Handling Fmoc-D-1-Nal-OH requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used. The compound is classified under WGK Germany 3, indicating a higher hazard level.
How is Fmoc-D-1-Nal-OH packed, shipped, and exported?
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Fmoc-D-1-Nal-OH is stored at 2-8°C. Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, experienced in handling and shipping such compounds internationally.
How can I request a sample or quote for Fmoc-D-1-Nal-OH?
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To request a sample or obtain a quotation for Fmoc-D-1-Nal-OH, please contact the Tech Serve Solutions sales team directly through our website or by phone.
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