Fmoc-Cys(tBu)-OH
Fmoc-Cys(tBu)-OH (CAS: 67436-13-9, C22H25NO4S) is an N-protected amino acid derivative featuring a tert-butyl protecting group on the cysteine thiol. With a molecular weight of 399.50 g/mol, it is a crucial building block in solid-phase peptide synthesis (SPPS). Its utility lies in protecting the reactive thiol group during peptide chain elongation, ensuring regioselective coupling and preventing side reactions.
- IUPAC
- Nα-Fmoc-S-tert-butyl-L-cysteine
- Synonyms
- N-alpha-Fmoc-S-tert-butyl-L-cysteineNα-Fmoc-S-tert-butyl-L-cysteine
Peptide Synthesis
Serves as a protected cysteine residue in solid-phase peptide synthesis (SPPS) for constructing complex peptide chains with high fidelity. The tert-butyl group effectively shields the thiol moiety from unwanted reactions during coupling steps.
Chemical Biology Research
Utilised in the synthesis of peptides for biochemical and biological studies, including protein mimetics, enzyme substrates, and modified peptides for drug discovery. It enables the incorporation of cysteine at specific positions within a peptide sequence.
Organic Synthesis
Acts as a versatile intermediate in the synthesis of various sulfur-containing organic molecules and complex chemical structures. Its protected functional groups allow for controlled transformations in multi-step synthetic routes.
| Molecular weight | 399.50 |
|---|---|
| Empirical formula | C22H25NO4S |
| Assay | ≥98.0% (HPLC) |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-Cys(tBu)-OH used for?
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Fmoc-Cys(tBu)-OH is primarily used as a protected building block in solid-phase peptide synthesis (SPPS) to incorporate cysteine residues into growing peptide chains. It protects the thiol group during synthesis.
What are the CAS number and formula for Fmoc-Cys(tBu)-OH?
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The CAS number is 67436-13-9, and the empirical formula is C22H25NO4S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-Cys(tBu)-OH with an assay of ≥98.0% (HPLC). We do not represent this product as USP, BP, or EP grade.
What safety precautions are necessary when handling Fmoc-Cys(tBu)-OH?
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Handling requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. The substance is classified under WGK Germany 3.
How is Fmoc-Cys(tBu)-OH stored and shipped?
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This compound should be stored at 2-8°C. Tech Serve Solutions exports chemicals globally, adhering to all necessary shipping regulations.
How can I request a quote or sample for Fmoc-Cys(tBu)-OH?
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Please contact our sales team via the website or your designated account manager to request a quotation or a product sample.
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