Fmoc-Cys(Mbzl)-OH
Fmoc-Cys(Mbzl)-OH (CAS: 136050-67-4), a protected derivative of L-cysteine, is a key building block in peptide synthesis. Its empirical formula is C26H25NO4S, with a molecular weight of 447.55 g/mol. This compound features an Fmoc-protected amine and a benzyl-protected thiol group, enabling selective deprotection strategies. It is commonly employed in solid-phase peptide synthesis (SPPS) and for creating complex peptide structures in research and chemical biology.
- IUPAC
- Fmoc-S-(4-methylbenzyl)-L-cysteine
Peptide Synthesis
Fmoc-Cys(Mbzl)-OH is extensively used as a protected amino acid in Fmoc-based solid-phase peptide synthesis. The benzyl group on the cysteine thiol offers robust protection during coupling steps, allowing for controlled chain elongation.
Chemical Biology Research
This derivative facilitates the synthesis of peptides with modified cysteine residues, enabling studies in protein structure, function, and drug discovery. Its specific protection scheme is vital for creating peptides with desired biochemical properties.
Organic Synthesis
Beyond peptides, Fmoc-Cys(Mbzl)-OH serves as a versatile chiral synthon in complex organic synthesis, allowing the introduction of a protected cysteine moiety into various molecular scaffolds.
| Molecular weight | 447.55 |
|---|---|
| Empirical formula | C26H25NO4S |
| Assay | ≥99.0% |
| Optical activity | [α]20/D −37±2°, c = 1% in methanol |
| Storage temperature | 2-8°C |
| Melting point | 150-158 °C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-Cys(Mbzl)-OH used for?
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Fmoc-Cys(Mbzl)-OH is primarily used as a protected amino acid building block in Fmoc-based solid-phase peptide synthesis and in chemical biology research for constructing modified peptides.
What are the CAS number and chemical formula for Fmoc-Cys(Mbzl)-OH?
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The CAS number for Fmoc-Cys(Mbzl)-OH is 136050-67-4, and its empirical formula is C26H25NO4S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-Cys(Mbzl)-OH with an assay of ≥99.0%. We do not represent this product as USP, BP, or EP grade.
How should Fmoc-Cys(Mbzl)-OH be handled and stored?
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Handle Fmoc-Cys(Mbzl)-OH with appropriate personal protective equipment, including eyeshields, gloves, and a respirator filter (type N95 or P1). Store the chemical at 2-8°C.
Is Fmoc-Cys(Mbzl)-OH a hazardous substance?
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Yes, according to GHS classification, this substance has a WGK Germany rating of 3, indicating it is hazardous to water.
How is Fmoc-Cys(Mbzl)-OH shipped?
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Tech Serve Solutions can export Fmoc-Cys(Mbzl)-OH globally. Specific shipping and packaging details are available upon request.
How can I request a quote or sample?
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To request a quote or sample of Fmoc-Cys(Mbzl)-OH, please contact our sales department through the website or by phone.
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