Fmoc-Cys(Acm)-OH
Nα-Fmoc-S-acetaminomethyl-L-cysteine (CAS: 86060-81-3) is a protected amino acid derivative with the molecular formula C21H22N2O5S and a molecular weight of 414.47 g/mol. This compound is a crucial building block in solid-phase peptide synthesis (SPPS) and other complex organic syntheses. It offers a protected thiol group for controlled peptide chain elongation, enabling the creation of diverse peptide structures for research and development.
- IUPAC
- Nα-Fmoc-S-acetaminomethyl-L-cysteine
Peptide Synthesis
Utilised as a protected amino acid in solid-phase and solution-phase peptide synthesis. The Fmoc group allows for facile deprotection under mild basic conditions, while the acetaminomethyl (Acm) protecting group on the cysteine side chain prevents unwanted reactions during peptide coupling.
Chemical Biology Research
Serves as a reagent in chemical biology for constructing modified peptides. These modified peptides can be used to probe biological processes, develop diagnostic tools, or create therapeutic agents.
Organic Synthesis Intermediate
Acts as an intermediate in the synthesis of complex organic molecules where a protected cysteine residue is required. Its specific structure facilitates regioselective reactions and the introduction of functionalities.
| Molecular weight | 414.47 |
|---|---|
| Empirical formula | C21H22N2O5S |
| Assay | ≥95.0% (sum of enantiomers, HPLC) |
| Optical activity | [α]/D -33.0±2.0°, c = 1 in methanol |
| Storage temperature | 2-8°C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-Cys(Acm)-OH used for?
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Fmoc-Cys(Acm)-OH is primarily used in solid-phase peptide synthesis (SPPS) as a protected cysteine building block, enabling the controlled construction of peptide chains.
What is the CAS number and formula for Fmoc-Cys(Acm)-OH?
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The CAS number is 86060-81-3 and the empirical formula is C21H22N2O5S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-Cys(Acm)-OH with an assay of ≥95.0% (sum of enantiomers, HPLC). This product is suitable for research and chemical synthesis applications. TSS does not represent this product as USP, BP, or EP grade.
What are the safety and handling precautions for Fmoc-Cys(Acm)-OH?
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This compound is a Warning chemical, causing skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment including a dust mask type N95 (US), eyeshields, and gloves should be worn. Ensure good ventilation. P261, P305 + P351 + P338 precautions apply.
How is Fmoc-Cys(Acm)-OH packed, shipped, and exported?
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Fmoc-Cys(Acm)-OH is typically stored at 2-8°C. TSS is a specialist global supplier and exporter of fine chemicals, ensuring appropriate packaging and documentation for international shipment.
How can I request a sample or quote for Fmoc-Cys(Acm)-OH?
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To request a sample or a quotation, please contact the TSS sales team via our website or by phone, referencing the product name and CAS number.
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