Fmoc-Asp(OtBu)-OH
Fmoc-Asp(OtBu)-OH (CAS: 71989-14-5), with the molecular formula C23H25NO6 and a molecular weight of 411.45 g/mol, is a protected derivative of L-aspartic acid. It is a crucial building block in solid-phase peptide synthesis (SPPS), where the Fmoc group facilitates efficient deprotection under mild basic conditions, and the tert-butyl ester protects the side-chain carboxyl group. This compound is vital for constructing complex peptides and proteins in research and development.
- IUPAC
- Fmoc-L-aspartic acid 4-tert-butyl ester
Peptide Synthesis
Fmoc-Asp(OtBu)-OH is extensively used as a protected amino acid in solid-phase peptide synthesis. The Fmoc protecting group on the alpha-amino group allows for sequential coupling, while the tert-butyl ester protects the aspartic acid side chain from unwanted reactions during peptide chain elongation.
Chemical Biology Research
This derivative finds application in chemical biology for the synthesis of modified peptides and peptidomimetics. These molecules can serve as tools for studying biological processes, protein-protein interactions, and developing novel therapeutic agents.
Organic Synthesis
As a versatile building block, Fmoc-Asp(OtBu)-OH is employed in various organic synthesis pathways requiring chiral aspartic acid moieties with orthogonal protection strategies. Its defined structure and reactivity make it suitable for complex molecule construction.
| Molecular weight | 411.45 |
|---|---|
| Empirical formula | C23H25NO6 |
| Assay | ≥98.0% (HPLC) |
| Optical activity | [α]20/D −24±2°, c = 1% in DMF |
| Storage temperature | 2-8°C |
| Melting point | 148-150 °C (dec.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-Asp(OtBu)-OH used for?
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Fmoc-Asp(OtBu)-OH is primarily used as a protected amino acid building block in solid-phase peptide synthesis (SPPS) and in chemical biology research for creating complex peptides and related molecules.
What are the CAS number and formula for Fmoc-Asp(OtBu)-OH?
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The CAS number for Fmoc-Asp(OtBu)-OH is 71989-14-5, and its empirical formula is C23H25NO6.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-Asp(OtBu)-OH with an assay of ≥98.0% (HPLC). We do not represent this product as USP, BP, or EP grade.
How should Fmoc-Asp(OtBu)-OH be handled and stored?
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Handle Fmoc-Asp(OtBu)-OH with appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter. Store at 2-8°C to maintain stability.
Is Fmoc-Asp(OtBu)-OH a controlled substance?
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The provided data does not indicate that Fmoc-Asp(OtBu)-OH is a controlled substance.
How can I request a sample or quote for Fmoc-Asp(OtBu)-OH?
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To request a sample or a quote, please contact our sales team through the TSS website, providing the product name and CAS number (71989-14-5).
How is Fmoc-Asp(OtBu)-OH packed, shipped, and exported?
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Fmoc-Asp(OtBu)-OH is carefully packed to ensure product integrity during transit. Tech Serve Solutions, as a specialist global supplier and exporter, adheres to all relevant shipping and export regulations for chemical compounds.
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